Technology platform for implantation of CMOS microchip with transparent hermetic package

• Project/Area Number: 18K04265
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 21060:Electron device and electronic equipment-related
• Research Institution: Toyohashi University of Technology
• Principal Investigator: Noda Toshihiko 豊橋技術科学大学, エレクトロニクス先端融合研究所, 准教授 (20464159)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 体内埋め込み型機器 / CMOS集積回路 / パッケージ技術 / 体内埋め込み機器 / 神経刺激デバイス / 気密封止 / 透明パッケージ / CMOS / 体内埋め込み

Outline of Final Research Achievements

Implantable medical devices are expected to become more important for maintaining a high quality of life (QOL) while living with various diseases. In this study, an ultra-small hermetically sealed package technology that ensures high reliability and durability for implantable medical devices has been developed. A highly durable assembly method using inorganic materials was proposed and completed a proof-of-concept device capable of nerve stimulation. Functional demonstration of the prototype device was performed successfully.

Academic Significance and Societal Importance of the Research Achievements

CMOS集積回路は体内埋込み型機器の高度な制御や高品質な信号計測に不可欠である。本研究では，超小型のCMOS集積回路を安全かつ長期安定的に体内に埋め込む方法の一例を示す事ができ，本技術に基づく体内埋め込み型機器の発展が期待できる。

Research Products

• [Int'l Joint Research] National Chiao Tung University(その他の国・地域 台湾)
• [Int'l Joint Research] National Chiao Tung University/National Taipei University of Technology(その他の国・地域)
• [Journal Article] A Multi-Electrode CMOS Integrated Device for Retinal Prosthesis Using Ceramic Substrate (2021)
  • Author(s): 笹川 清隆，森 康登，春田 牧人，鐘堂 健三，寺澤 靖雄，竹原 浩成，田代 洋行，野田 俊彦，德田 崇，太田 淳
  • Volume: J104-C
  • Issue: 6
  • Pages: 177-184
  • DOI: 10.14923/transelej.2020JCI0019
  • ISSN: 1881-0217
  • Year and Date: 2021-06-01
  • Peer Reviewed
• [Journal Article] Improved Charge Pump Design and Ex Vivo Experimental Validation of CMOS 256-Pixel Photovoltaic-Powered Subretinal Prosthetic Chip (2020)
  • Author(s): Kuo Po-Han、Wong Oi-Ying、Tzeng Chi-Kuan、Wu Pu-Wei、Chiao Chuan-Chin、Chen Po-Hung、Chen Po-Chun、Tsai Yueh-Chun、Chu Fang-Liang、Ohta Jun、Tokuda Takashi、Noda Toshihiko、Wu Chung-Yu
  • Journal Title: IEEE Transactions on Biomedical Engineering Volume: 67 Issue: 5 Pages: 1490-1504
  • DOI: 10.1109/tbme.2019.2938807
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CMOS 256-Pixel/480-Pixel Photovoltaic-Powered Subretinal Prosthetic Chips With Wide Image Dynamic Range and Bi/Four-Directional Sharing Electrodes and Their Ex Vivo Experimental Validations With Mice (2020)
  • Author(s): Wu Chung-Yu、Tseng Chi-Kuan、Liao Jung-Hsing、Chiao Chuan-Chin、Chu Fang-Liang、Tsai Yueh-Chun、Ohta Jun、Noda Toshihiko
  • Journal Title: IEEE Transactions on Circuits and Systems I: Regular Papers Volume: 67 Issue: 10 Pages: 3273-3283
  • DOI: 10.1109/tcsi.2020.2976716
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Retinal Prosthesis Using Thin-Film Devices on a Transparent Substrate and Wireless Power Transfer (2020)
  • Author(s): Tomioka Keisuke、Toyoda Kohei、Ishizaki Toshio、Noda Toshihiko、Ohta Jun、Kimura Mutsumi
  • Journal Title: IEEE Transactions on Electron Devices Volume: 67 Issue: 2 Pages: 529-534
  • DOI: 10.1109/ted.2019.2960295
  • Peer Reviewed
• [Journal Article] Performance improvement and in vivo demonstration of a sophisticated retinal stimulator using smart electrodes with built-in CMOS microchips (2018)
  • Author(s): Noda Toshihiko、Nakano Yukari、Terasawa Yasuo、Haruta Makito、Sasagawa Kiyotaka、Tokuda Takashi、Ohta Jun
  • Journal Title: Japanese Journal of Applied Physics Volume: 57 Issue: 10 Pages: 1002B3-1002B3
  • DOI: 10.7567/jjap.57.1002b3
  • NAID: 210000149685
  • Peer Reviewed / Open Access
• [Journal Article] A CMOS 256-pixel Photovoltaics-powered Implantable Chip with Active Pixel Sensors and Iridium-oxide Electrodes for Subretinal Prostheses (2018)
  • Author(s): Wu Chung-Yu、Kuo Po-Han、Lin Po-Kang、Chen Po-Chun、Sung Wei-Jie、Ohta Jun、Tokuda Takashi、Noda Toshihiko
  • Journal Title: Sensors and Materials Volume: 30 Pages: 193
  • DOI: 10.18494/SAM.2018.1664
  • ISSN: 0914-4935, 2435-0869
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Electrochemical Evaluation of Geometrical Effect and Three-dimensionalized Effect of Iridium Oxide Electrodes Used for Retinal Stimulation (2018)
  • Author(s): Noda Toshihiko、Noda Yoshiko、Chen Po-Chun、Haruta Makito、Sasagawa Kiyotaka、Tokuda Takashi、Wu Chung-Yu、Ohta Jun
  • Journal Title: Sensors and Materials Volume: 30 Pages: 213
  • DOI: 10.18494/SAM.2018.1717
  • ISSN: 0914-4935, 2435-0869
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional Validation of Intelligent Retinal Stimulator Using Microchip-embedded Smart Electrode (2018)
  • Author(s): Noda Toshihiko、Haruta Makito、Sasagawa Kiyotaka、Tokuda Takashi、Ohta Jun
  • Journal Title: Sensors and Materials Volume: 30 Pages: 167
  • DOI: 10.18494/SAM.2018.1649
  • ISSN: 0914-4935, 2435-0869
  • Peer Reviewed / Open Access
• [Presentation] A CMOS 256-Pixel Self-Photovoltaics-Powered Subretinal Prosthetic Chip with Wide Image Dynamic Range and Shared Electrodes and Its in Vitro Experimental Results on Rd1 Mice (2019)
  • Author(s): Chung Yu Wu , Chi Kuan Tzeng , Shih Yun Huang , Fang Liang Chu , Chuan Chin Chiao , Yueh Chun Tsai , Jun Ohta , Toshihiko Noda
  • Organizer: IEEE Midwest Symposium on Circuits and Systems
  • Int'l Joint Research
• [Presentation] 人工視覚システムにおける制御回路搭載埋植ユニットへの高速化・低消費電力通信の検討 (2019)
  • Author(s): 秦 真誉, 森 康登, 張 家綺, 遠藤 広基, 鐘堂 健三, 寺澤 靖雄, 野田 俊彦, 徳田 崇, 春田 牧人, 笹川 清隆, 太田 淳
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] 人工視覚用ハニカム型CMOS スマート電極アレイの開発と評価 (2019)
  • Author(s): 遠藤 広基, 野田 俊彦, 寺澤 靖雄, 春田 牧人, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] 高解像度人工視覚システム向けスマート電極デバイスの高速信号伝送方式の検討 (2019)
  • Author(s): 森 康登, ChiaChi Chang, 遠藤 広基, 秦 真誉, 野田 俊彦, 鐘堂 健三, 寺澤 靖雄, 春田 牧人, 笹川 清隆, 徳田 崇, 太田 淳
  • Organizer: LSIとシステムのワークショップ2019