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Fabrication of gold nanorod composites with chiral core-shell structure

Research Project

Project/Area Number 18K04724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 26030:Composite materials and interfaces-related
Research InstitutionUniversity of Yamanashi

Principal Investigator

Shinmori Hideyuki  山梨大学, 大学院総合研究部, 准教授 (40311740)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords金ナノロッド / 自己組織化 / タンパク質 / キラル組織体 / シリカコーティング / コアシェル構造 / 熱安定性 / CD活性 / side-by-side型会合 / end-to-end型会合 / 金属ナノロッド / キラル / 不斉記憶
Outline of Final Research Achievements

The synthesis of a silica shell over chiral gold-nanorod assemblies produced using proteins as chiral sources and their thermal stabilization for chirality were investigated. We successfully prepared chiroptical core-shell nanoparticles by the surface silica coating onto chiral-organized arrays of gold nanorods by plasma proteins in colloidal solution. The core-shell nanoparticles contained plural gold nanorods in the core and were removed chiral proteins. Also, the chiroptical activity of the core-shell nanoparticles was thermally stabilized by the silica coating. Thus, stable silica-coated chiral gold-nanorod assemblies with plasmonic circular dichroism response, which crucial for practical application of chiral nanomaterials, can be fabricated by the core-shell nanostructures.

Academic Significance and Societal Importance of the Research Achievements

光学活性を有する複合ナノ材料は安定性が高く、多くの情報を記憶でき、実用化が十分期待される物質である。そこで本研究では、多様性を持つタンパク質によって棒状の金微粒子をらせん状に配列させ、そのナノ界面を無機系シリカでコーティングすることで頑丈で安定的に光学的不斉シグナルを発する、即ち不斉記憶された複合ナノ材料を創出した。これは、光学的マルチ情報を組み込んだ新たなナノマテリアルと成り得るために学術的に意義深い。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (38 results)

All 2021 2020 2019 2018

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 4 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021

    • Author(s)
      S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, H. Shinmori, T. Inukai, T. Kondo, K. Suzuki-Inoue
    • Journal Title

      blood advances

      Volume: 5 Issue: 7 Pages: 2017-2026

    • DOI

      10.1182/bloodadvances.2020001698

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] アキラルな金ナノロッドより創出される巨大な光学活性2020

    • Author(s)
      新森英之, 望月ちひろ
    • Journal Title

      プラズモニック化学研究会Newsletter

      Volume: 2020 Pages: 5-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオ関連キラル超構造化や光学的触媒能が付与された金ナノ粒子の創製2020

    • Author(s)
      新森英之, 望月ちひろ, 篠原英
    • Journal Title

      触媒

      Volume: 63 Pages: 27-32

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acid-base controllable singlet oxygen generation in supramolecular porphyrin-gold nanoparticle composites tethered by rotaxane linkers2020

    • Author(s)
      A. Shinohara, C. Pan, L. Wang, H. Shinmori
    • Journal Title

      The Journal of Porphyrins and Phthalocyanines

      Volume: 24 Issue: 01n03 Pages: 171-180

    • DOI

      10.1142/s108842461950086x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in β-(1,3-1,6)-D-Glucan with On-Off Switch2020

    • Author(s)
      S. Hino, S. Satake, H. Shinmori, S. Kawabata, K. Koumoto, T. Suzuki, T. Nagasaki, K. Sugikawa, R. Kawasaki, A. Ikeda
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 15 Issue: 3 Pages: 365-370

    • DOI

      10.1002/asia.201901582

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrogen Sulfide Mediates Tumor Cell Resistance to Thioredoxin Inhibitor2020

    • Author(s)
      Z. Mao, X. Yang, S. Mizutani, Y. Huang, Z. Zhang, H. Shinmori, K. Gao, J. Yao
    • Journal Title

      Frontiers in Oncology

      Volume: 10 Pages: 252-252

    • DOI

      10.3389/fonc.2020.00252

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] アキラルな金ナノロッドより創出される巨大な光学活性2020

    • Author(s)
      新森英之, 望月ちひろ
    • Journal Title

      プラズモニック化学研究会 Newsletter

      Volume: 2020

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] 酒石酸を用いた金ナノ粒子の合成とアミノ酸の色調変化によるキラル識別2020

    • Author(s)
      新森英之
    • Journal Title

      化学工業

      Volume: 71

    • Related Report
      2019 Research-status Report
  • [Journal Article] Screening for <i>Lipomyces</i> strains with high ability to accumulate lipids from renewable resources2019

    • Author(s)
      M. Yanagiba, K. Masaki, H. Shinmori, T. Naganuma
    • Journal Title

      The Journal of General and Applied Microbiology

      Volume: 65 Issue: 2 Pages: 80-87

    • DOI

      10.2323/jgam.2018.05.006

    • NAID

      130007651710

    • ISSN
      0022-1260, 1349-8037
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells2019

    • Author(s)
      Y. Nakamura, T. Sasaki, C. Mochizuki, K. Ishimaru, S. Koizumi, H. Shinmori, K. Suzuki-Inoue, A. Nakao
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 15958-15958

    • DOI

      10.1038/s41598-019-52449-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of Liquid Culture Conditions for Triacylglycerol Production from Waste Peach by <i>Lipomyces</i> Wild-type Strain2019

    • Author(s)
      Yanagiba Mana、Shinmori Hideyuki、Naganuma Takafumi
    • Journal Title

      Journal of Oleo Science

      Volume: 68 Issue: 3 Pages: 245-249

    • DOI

      10.5650/jos.ess18168

    • NAID

      130007605888

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] High photodynamic activities of water-soluble inclusion complexes of 5,15-diazaporphyrins in cyclodextrin2019

    • Author(s)
      S. Satake, H. Shinmori, S. Kawabata, K. Sugikawa, H. Funabashi, A. Kuroda, A. Ikeda
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 17 Issue: 12 Pages: 3141-3149

    • DOI

      10.1039/c9ob00101h

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cobalt hematoporphyrin inhibits CLEC-2?podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice2018

    • Author(s)
      Tsukiji Nagaharu、Osada Makoto、Sasaki Tomoyuki、Shirai Toshiaki、Satoh Kaneo、Inoue Osamu、Umetani Norihiko、Mochizuki Chihiro、Saito Tamio、Kojima Soichi、Shinmori Hideyuki、Ozaki Yukio、Suzuki-Inoue Katsue
    • Journal Title

      Blood Advances

      Volume: 2 Issue: 17 Pages: 2214-2225

    • DOI

      10.1182/bloodadvances.2018016261

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] シリカ被膜によって安定化された高分散性金ナノ粒子の開発2018

    • Author(s)
      新森英之, 徳丸佳奈, 望月ちひろ
    • Journal Title

      鉱山

      Volume: 71 Pages: 225-232

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] ダンシル基を界面導入した発光性シリカコート金ナノロッドの合成2021

    • Author(s)
      新森英之、山崎圭
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 微粒子界面で発光ラベル化されたシリカコート金ナノロッドの構築2020

    • Author(s)
      新森英之
    • Organizer
      イノベーション・ジャパン2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 光化学的機能を有するコアシェル型チタニアコート金ナノロッドの開発2020

    • Author(s)
      水谷彩由実、新森英之
    • Organizer
      第10回CSJ化学フェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 発光性を有するコアシェル型シリカコート金ナノロッドの階層的合成2020

    • Author(s)
      山崎圭、新森英之
    • Organizer
      第10回CSJ化学フェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生体関連化学での利用に向けた金ナノロッドの分散安定性の改良法2020

    • Author(s)
      新森英之、徳丸佳奈
    • Organizer
      日本農芸化学会関東支部2020年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 階層的合成による発光性シリカコート金ナノロッドの構築2020

    • Author(s)
      山崎圭、新森英之
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Research-status Report
  • [Presentation] キラルに配列制御された金ナノロッド集合体の光学特性2019

    • Author(s)
      新森英之
    • Organizer
      第16回プラズモニック化学シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 光線力学的療法に向けたポルフィリン修飾金ナノ粒子型光増感物質の機能制御2019

    • Author(s)
      新森 英之、篠原 英
    • Organizer
      日本農芸化学会関東支部2019年度大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生体プローブとして有用な金ナノロッドの化学的界面改変2019

    • Author(s)
      山崎圭、新森英之
    • Organizer
      令和元年度やまなし産学官連携研究交流事業
    • Related Report
      2019 Research-status Report
  • [Presentation] 光化学的機能を有するコアシェル型金ナノロッドの開発2019

    • Author(s)
      水谷彩由実、新森英之
    • Organizer
      令和元年度やまなし産学官連携研究交流事業
    • Related Report
      2019 Research-status Report
  • [Presentation] 金ナノロッドのシリカコーティングにおけるアミノ酸の影響2019

    • Author(s)
      町田有希、新森英之
    • Organizer
      第9回CSJ化学フェスタ2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Photoinduced Singlet Oxygen Generation Regulated by Ligand Exchange Reactions of Porphyrin-appended Gold Nanoparticles2019

    • Author(s)
      H. Shinmori, A. Shinohara
    • Organizer
      29th Annual Meeting of MRS-J
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 酒石酸を用いた金ナノ粒子の合成とアミノ酸の色調変化によるキラル識別2019

    • Author(s)
      新森英之
    • Organizer
      JST新技術説明会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] シリカコート金ナノロッドの分散性と熱安定性2019

    • Author(s)
      新森英之、徳丸佳奈、望月ちひろ
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] シリカ被膜によって安定化された高分散性金ナノ粒子の開発2018

    • Author(s)
      新森英之
    • Organizer
      金属鉱山会 平成30年度 第1回講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ダンベル型金ナノ粒子の熱力学的安定性における界面シリカ被膜の影響2018

    • Author(s)
      伏見麻奈美、新森英之
    • Organizer
      第69回コロイドおよび界面化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] L-酒石酸還元金ナノ粒子を用いたアミノ酸の選択的検知と不斉識別2018

    • Author(s)
      新森英之、酒井皓大
    • Organizer
      日本農芸化学会関東支部2018年度大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 選択的アミノ酸認識能を有する酒石酸修飾金ナノ粒子の合成2018

    • Author(s)
      酒井皓大、新森英之
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Forever and ever-未来永劫-2015年ノーベル医学・生理学賞受賞記念モニュメント2018

    • Author(s)
      村松俊夫、新森英之
    • Organizer
      環境芸術学会第19回大会
    • Related Report
      2018 Research-status Report
  • [Book] 金属ナノ粒子・微粒子の合成技術と応用2021

    • Author(s)
      新森英之
    • Publisher
      サイエンス&テクノロジー株式会社
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 標識化シリカコート金ナノロッド及びその製造方法2021

    • Inventor(s)
      新森英之, 山崎圭, 篠原英
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-209844
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] LABELED SILICA-COATED GOLD NANORODS AND A METHOD FOR PRODUCING THE SAME2021

    • Inventor(s)
      H. Shinmori et al.
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 標識化シリカコート金ナノロッド及びその製造方法2020

    • Inventor(s)
      新森英之, 山崎圭, 篠原英
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-002077
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] ヒドロキシ酸還元型金ナノ粒子を用いたアミノ酸の色調変化による選択的検出と不斉識別2018

    • Inventor(s)
      新森英之、酒井皓大
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-178008
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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