Development of novel High Entropy Alloys for metallic biomaterials based on the new alloy design

• Project/Area Number: 18K04750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 26040:Structural materials and functional materials-related
• Research Institution: Osaka University
• Principal Investigator: Nagase Takeshi 大阪大学, 超高圧電子顕微鏡センター, 准教授 (50362661)
• Co-Investigator(Kenkyū-buntansha): 當代 光陽 新居浜工業高等専門学校, 環境材料工学科, 准教授 (10610800)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 生体材料 / ハイエントロピー合金 / 熱力学計算 / 凝固 / 鋳造 / 高エントロピー合金 / 材料組織 / 合金設計

Outline of Final Research Achievements

Solidification microstructure in TiNbTaZrMo high entropy alloys for metallic biomaterial (BioHEA) was investigated focusing on the segregation behavior. The segregation was investigated by the electron microscopy and the thermodynamic calculation. Non-equiatomic Ti1.4Zr1.4Nb0.6Ta0.6Mo0.6 BioHEA with superior high strength and bio-compatibility was developed.

Academic Significance and Societal Importance of the Research Achievements

高齢化社会をむかえた現在において Quolity of Life (QOL）を支える新たな生体用金属新素材の開発が急務になっている。本研究により、生体適合性はCP-Tiと同程度でありながらその力学特性は既存のTi合金を大きく上回る生体用金属新素材、すなわち、強度-生体適合性バランスにおいて従来材料では実現できない特性をしめす生体用金属新素材の開発を達成した。

Research Products

• [Journal Article] Design and development of Ti-Zr-Hf-Nb-Ta-Mo high-entropy alloys for metallic biomaterials (2021)
  • Author(s): Iijima Yuuka、Nagase Takeshi、Matsugaki Aira、Wang Pan、Ameyama Kei、Nakano Takayoshi
  • Journal Title: Materials & Design Volume: 202 Pages: 109548-109548
  • DOI: 10.1016/j.matdes.2021.109548
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Solid State Amorphization and Alloy Parameters for High Entropy Alloys (2021)
  • Author(s): Nagase Takeshi
  • Journal Title: Materials Science Forum Volume: 1016 Pages: 990-996
  • DOI: 10.4028/www.scientific.net/msf.1016.990
  • Peer Reviewed / Open Access
• [Journal Article] Development of Fe–P–C–Cu Immiscible Amorphous Alloys with Liquid Phase Separation (2020)
  • Author(s): Nagase Takeshi、Terai Tomoyuki、Matsumuro Mitsuaki、Takemura Mamoru
  • Journal Title: ISIJ International Volume: 60 Issue: 11 Pages: 2615-2624
  • DOI: 10.2355/isijinternational.ISIJINT-2020-211
  • NAID: 130007940338
  • ISSN: 0915-1559, 1347-5460
  • Year and Date: 2020-11-15
  • Peer Reviewed / Open Access
• [Journal Article] Alloy Design and Fabrication of Ingots of Al–Mg–Li–Ca Light-Weight Medium Entropy Alloys (2020)
  • Author(s): Nagase Takeshi、Terayama Akira、Nagaoka Takashi、Fuyama Nobuyuki、Sakamoto Tatsuaki
  • Journal Title: MATERIALS TRANSACTIONS Volume: 61 Issue: 7 Pages: 1369-1380
  • DOI: 10.2320/matertrans.F-M2020825
  • NAID: 130007864020
  • ISSN: 1345-9678, 1347-5320
  • Year and Date: 2020-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Development and Perspectives of High Entropy alloys composed by light metal elements and that for metallic biomaterials with BCC (2020)
  • Author(s): 當代 光陽、永瀬 丈嗣、中野 貴由
  • Journal Title: Journal of Japan Institute of Light Metals Volume: 70 Issue: 1 Pages: 14-23
  • DOI: 10.2464/jilm.70.14
  • NAID: 130007837642
  • ISSN: 0451-5994, 1880-8018
  • Year and Date: 2020-01-25
  • Peer Reviewed / Open Access
• [Journal Article] Alloy Design, Thermodynamics, and Electron Microscopy of Ternary Ti-Ag-Nb Alloy with Liquid Phase Separation (2020)
  • Author(s): Nagase Takeshi
  • Journal Title: Materials Volume: 13 Issue: 22 Pages: 5268-5268
  • DOI: 10.3390/ma13225268
  • Peer Reviewed / Open Access
• [Journal Article] Fabrication of Casting Products in Cu–Zn–Mn–Ni Medium Entropy Brasses (2020)
  • Author(s): 永瀬 丈嗣、柴田 顕弘、松室 光昭、武村 守、千星 聡
  • Journal Title: Journal of Japan Institute of Copper Volume: 59 Issue: 1 Pages: 24-31
  • DOI: 10.34562/jic.59.1_24
  • NAID: 130007940892
  • ISSN: 1347-7234, 2435-872X
  • Peer Reviewed
• [Journal Article] Liquid Phase Separation in Ag-Co-Cr-Fe-Mn-Ni, Co Cr-Cu-Fe-Mn-Ni and Co-Cr-Cu-Fe-Mn-Ni-B High Entropy Alloys for Biomedical Application (2020)
  • Author(s): Nagase Takeshi、Todai Mitsuharu、Nakano Takayoshi
  • Journal Title: Crystals Volume: 10 Issue: 6 Pages: 527-527
  • DOI: 10.3390/cryst10060527
  • Peer Reviewed / Open Access
• [Journal Article] Development of Ti-Zr-Hf-Y-La high-entropy alloys with dual hexagonal-close-packed structure (2020)
  • Author(s): Nagase Takeshi、Todai Mitsuharu、Nakano Takayoshi
  • Journal Title: Scripta Materialia Volume: 186 Pages: 242-246
  • DOI: 10.1016/j.scriptamat.2020.05.033
  • Peer Reviewed / Open Access
• [Journal Article] Alloy Design and Fabrication of Ingots of Al-Mg-Li-Ca Light-Weight Medium Entropy Alloys (2019)
  • Author(s): 永瀬 丈嗣、寺山 朗、長岡 孝、府山 伸行、阪本 辰顕
  • Journal Title: Journal of Japan Foundry Engineering Society Volume: 91 Issue: 10 Pages: 717-729
  • DOI: 10.11279/jfes.91.717
  • NAID: 130007740198
  • ISSN: 1342-0429, 2185-5374
  • Year and Date: 2019-10-25
  • Peer Reviewed
• [Journal Article] Solidification Microstructures of the Ingots Obtained by Arc Melting and Cold Crucible Levitation Melting in TiNbTaZr Medium-Entropy Alloy and TiNbTaZrX (X = V, Mo, W) High-Entropy Alloys (2019)
  • Author(s): Nagase Takeshi、Mizuuchi Kiyoshi、Nakano Takayoshi
  • Journal Title: Entropy Volume: 21 Issue: 5 Pages: 483-483
  • DOI: 10.3390/e21050483
  • Peer Reviewed / Open Access
• [Journal Article] Development of non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials (2019)
  • Author(s): Hori Takao、Nagase Takeshi、Todai Mitsuharu、Matsugaki Aira、Nakano Takayoshi
  • Journal Title: Scripta Materialia Volume: 172 Pages: 83-87
  • DOI: 10.1016/j.scriptamat.2019.07.011
  • Peer Reviewed / Open Access
• [Journal Article] Alloy design and fabrication of ingots in Cu-Zn-Mn-Ni-Sn high-entropy and Cu-Zn-Mn-Ni medium-entropy brasses (2019)
  • Author(s): Nagase Takeshi、Shibata Akihiro、Matsumuro Mitsuaki、Takemura Mamoru、Semboshi Satoshi
  • Journal Title: Materials & Design Volume: 181 Pages: 107900-107900
  • DOI: 10.1016/j.matdes.2019.107900
  • Peer Reviewed / Open Access
• [Journal Article] Development of Fe-Co-Cr-Mn-Ni-C high entropy cast iron (HE cast iron) available for casting in air atmosphere (2019)
  • Author(s): Nagase Takeshi、Kakeshita Tomoyuki、Matsumura Kotaro、Nakazawa Koichiro、Furuya Satoshi、Ozoe Nobuaki、Yoshino Katsumi
  • Journal Title: Materials & Design Volume: 184 Pages: 108172-108172
  • DOI: 10.1016/j.matdes.2019.108172
  • Peer Reviewed / Open Access
• [Journal Article] Microstructure of equiatomic and non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials (2018)
  • Author(s): Nagase Takeshi、Todai Mitsuharu、Hori Takao、Nakano Takayoshi
  • Journal Title: Journal of Alloys and Compounds Volume: 753 Pages: 412-421
  • DOI: 10.1016/j.jallcom.2018.04.082
  • Peer Reviewed / Open Access
• [Journal Article] 高エントロピー合金の特徴と鋳造合金としての実用化に向けた研究(<特集>注目の新規金属材料「高エントロピー合金」) (2018)
  • Author(s): 永瀬丈嗣
  • Journal Title: Journal of the Society of Mechanical Engineers Volume: 121 Issue: 1192 Pages: 8-11
  • DOI: 10.1299/jsmemag.121.1192_8
  • NAID: 130007397551
• [Journal Article] Solid state amorphization of metastable Al 0.5 TiZrPdCuNi high entropy alloy investigated by high voltage electron microscopy (2018)
  • Author(s): Nagase Takeshi、Takeuchi Akira、Amiya Kenji、Egami Takeshi
  • Journal Title: Materials Chemistry and Physics Volume: 210 Pages: 291-300
  • DOI: 10.1016/j.matchemphys.2017.07.071
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Microstructure of Co-Cr-Fe-Mn-Ni-Cu and Co-Cr-Fe-Mn-Ni-Ag High Entropy Alloys with Liquid Phase Separation (2018)
  • Author(s): Nagase Takeshi
  • Journal Title: Materials Science Forum Volume: 941 Pages: 1238-1241
  • DOI: 10.4028/www.scientific.net/msf.941.1238
  • Peer Reviewed
• [Presentation] ハイエントロピースチールとハイエントロピー鋳鉄 (2020)
  • Author(s): 永瀬丈嗣
  • Organizer: 日本金属学会関西支部鉄鋼プロセス研究会・材料化学研究会
  • Invited
• [Presentation] bcc型TiNbTaZRMo BioHEAの力学特性向上に向けた合金設計 (2020)
  • Author(s): 當代光陽, 川堀龍, 永瀬丈嗣, 松垣あいら, 中野貴由
  • Organizer: 日本金属学会
• [Presentation] bcc型TiNbTaZrMo系ハイエントロピー合金へのB添加の影響 (2020)
  • Author(s): 川堀龍, 當代光陽, 永瀬丈嗣, 中野貴由
  • Organizer: 日本金属学会
• [Presentation] レーザ積層造形法による生体用ハイエントロピー合金（BioHEA）の創製 (2020)
  • Author(s): 小笹良輔, 中野加菜, 石本卓也, 松垣あいら, 永瀬丈嗣, 當代光陽, 中野貴由
  • Organizer: 日本バイオマテリアル学会関西ブロック 第15回若手研究発表会
• [Presentation] ハイエントロピー合金の凝固組織の特徴と特異性 (2020)
  • Author(s): 永瀬丈嗣
  • Organizer: 日本鋳造工学会関西支部令和2年度 秋季支部講演大会
• [Presentation] 銅（Cu）とハイエントロピー合金 (2020)
  • Author(s): 永瀬丈嗣
  • Organizer: 日本銅学会
• [Presentation] 冷間圧延されたCu-Zn-Mn-Niミディアムエントロピー黄銅板の機械的性質 (2020)
  • Author(s): 鞭目龍之介, 李相民, 永瀬丈嗣, 松本良, 宇都宮裕
  • Organizer: 日本銅学会
• [Presentation] レーザ積層造形法によるBioHEAの作製と特異組織形成 (2020)
  • Author(s): 中野加菜, 小笹良輔, 石本卓也, 松垣あいら, 永瀬丈嗣, 當代光陽, 中野貴由
  • Organizer: 日本金属学会
• [Presentation] レーザ積層造形法による生体用ハイエントロピー合金の造形 (2020)
  • Author(s): 西川侑希, 石本卓也, 松垣あいら, 小笹良輔, 永瀬丈嗣, 中野貴由
  • Organizer: 日本金属学会
• [Presentation] Solidification microstructure analysis in AlTi0.5ZrCuNiPd High Entropy Glasses and High Entropy Alloys (2019)
  • Author(s): T. Nagase, A. Takeuchi, K. Amiya, T. Egami
  • Organizer: 粉体粉末冶金協会 平成31年度春季大会
• [Presentation] 混合エンタルピーの観点からみた金属ガラス・ハイエントロピー合金（3d-HEA, RHEA, LW-HEA, HE Brass）の特徴 (2019)
  • Author(s): 永瀬丈嗣, 寺山朗, 長岡孝, 府山伸行, 阪本辰顕, 柴田顕弘, 松室光昭, 武村守, 千星聡
  • Organizer: 粉体粉末冶金協会 平成31年度春季大会
• [Presentation] 生体用bcc型ハイエントロピー合金におけるヤング率 (2019)
  • Author(s): 川堀龍, 當代光陽, 永瀬丈嗣, 中野貴由
  • Organizer: 日本金属学会2019年秋期講演大会
• [Presentation] Ti-Zr-Hf-Co-Cr-Mo生体ハイエントロピー合金の組織と特性 (2019)
  • Author(s): 飯島佑香, 永瀬丈嗣, 松垣あいら, 飴山惠, 中野貴由
  • Organizer: 日本金属学会2019年秋期講演大会
• [Presentation] ハイエントロピー黄銅の材料設計とその特性 (2019)
  • Author(s): 永瀬丈嗣, 柴田顕弘, 松室光昭, 武村守, 千星聡
  • Organizer: 日本銅学会第59回講演大会
• [Presentation] Materials project を利用したアモルファス合金・ハイエントロピー合金の設計 (2019)
  • Author(s): 永瀬丈嗣
  • Organizer: 日本材料学会 第5回材料WEEK
• [Presentation] Development of equi-atomic TiNbTaZrMo high entropy alloys for metallic biomaterials (2018)
  • Author(s): T. Nagase, M. Todai, T. Nakano
  • Organizer: The Second International Conference on High-Entropy Materials (ICHEM 2018)
  • Int'l Joint Research / Invited
• [Presentation] Influence of casting process on the solidification microstructure of TiNbTaZrMo high-entropy alloys for metallic biomaterials (2018)
  • Author(s): T. Nagase, K. Mizuuchi, T. Nakano
  • Organizer: Japan Foundary Society (JFS)