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Bio-inspired technique for preparation of millicapsules in air

Research Project

Project/Area Number 18K04815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 27010:Transport phenomena and unit operations-related
Research InstitutionKagoshima University

Principal Investigator

Takei Takayuki  鹿児島大学, 理工学域工学系, 教授 (90468059)

Co-Investigator(Kenkyū-buntansha) 吉田 昌弘  鹿児島大学, 理工学域工学系, 教授 (50315397)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsカプセル / バイオインスパイアード / 気相 / リキッドマーブル
Outline of Final Research Achievements

In this study, millimeter-sized matrix and core/shell-type capsules were prepared using liquid marbles in air. Matrix-type capsules were prepared by photopolymerization of liquid hydrophobic monomer marbles containing ingredients. Ingredients could be encapsulated with high efficiency. Core/shell capsules were prepared by photopolymerization of the liquid monomer marbles injected with an immiscible water droplet. Interfacial thermodynamic prediction of internal configuration of capsules indicated successful formation of core/shell capsules. However, photopolymerization of the liquid marbles in a static condition resulted in formation of not only core/shell capsules but also acorn-type capsules. Furthermore, the core/shell capsules were distorted and the shell thickness was not uniform. Rolling of the liquid marbles, which generated centrifugal force inside of the liquid marbles, was effective to prepare spherical capsules with highly uniform shell thickness.

Academic Significance and Societal Importance of the Research Achievements

本研究のカプセル作製法は、カプセル中に内包されずにロスされてしまう有用物質の量を劇的に減らすことができるため、製造コストの削減につながる。したがって、従来技術ではコストの問題により商品化が不可能と見なされてきた様々なカプセル製品の商品化につながり、その社会的意義は大きい。また、カプセル内部構造の制御法のほとんどは、カプセルが液相中で調製されることを前提として提案されたものであり、それとは表面/界面張力や作用する浮力が大きく異なる気相中でのカプセル内部構造の制御指針を確立できており、実用的のみならず学術的な価値も極めて高い。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] Griffith University(オーストラリア)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Fabrication of Millicapsules from Slurry of Ingredient Particles and Monomer Liquid on a Superamphiphobic Surface2020

    • Author(s)
      Takei Takayuki、Takao Rio、Saito Takuya、Tajiri Nami、Yoshida Masahiro
    • Journal Title

      KAGAKU KOGAKU RONBUNSHU

      Volume: 46 Issue: 1 Pages: 8-12

    • DOI

      10.1252/kakoronbunshu.46.8

    • NAID

      130007787551

    • ISSN
      0386-216X, 1349-9203
    • Year and Date
      2020-01-20
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrophobically-modified gelatin hydrogel as a carrier for charged hydrophilic drugs and hydrophobic drugs2020

    • Author(s)
      Takei Takayuki、Yoshihara Ryosuke、Danjo So、Fukuhara Yoshiki、Evans Courtney、Tomimatsu Rio、Ohzuno Yoshihiro、Yoshida Masahiro
    • Journal Title

      International Journal of Biological Macromolecules

      Volume: 149 Pages: 140-147

    • DOI

      10.1016/j.ijbiomac.2020.01.227

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Core-Shell Beads Made by Composite Liquid Marble Technology as A Versatile Microreactor for Polymerase Chain Reaction2020

    • Author(s)
      Sreejith Kamalalayam Rajan、Gorgannezhad Lena、Jin Jing、Ooi Chin Hong、Takei Takayuki、Hayase Gen、Stratton Helen、Lamb Krystina、Shiddiky Muhammad、Dao Dzung Viet、Nguyen Nam-Trung
    • Journal Title

      Micromachines

      Volume: 11 Issue: 3 Pages: 242-242

    • DOI

      10.3390/mi11030242

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Millimeter-sized capsules prepared using liquid marbles: encapsulation of ingredients with high efficiency and preparation of spherical core-shell capsules with highly uniform shell thickness using centrifugal force2019

    • Author(s)
      Takayuki Takei, Yumiko Yamasaki, Yudai Yuji, Shogo Sakoguchi, Yoshihiro Ozuno, Gen Hayase, Masahiro Yoshida
    • Journal Title

      Journal of Colloid and Interface Science

      Volume: 536 Pages: 414-423

    • DOI

      10.1016/j.jcis.2018.10.058

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimization of conditions for removal of 137Cs by Rhodococcus erythropolis CS98 immobilized in agarose hydrogel2018

    • Author(s)
      Takayuki Takei, Juri Nomura, Nguyen Duc Hanh, Yudai Yuji, Noriko Tomioka, Masahiro Yoshida
    • Journal Title

      Studies in Science and Technology

      Volume: 7 Issue: 2 Pages: 123-126

    • DOI

      10.11425/sst.7.123

    • NAID

      130007599068

    • ISSN
      2186-4942, 2187-1590
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 拡張係数によるミリカプセルの構造予測および遠心分離技術を利用した構造制御2018

    • Author(s)
      迫口 翔吾、武井 孝行、吉田 昌弘
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 撥液表面またはリキッドマーブルを利用した微生物包括疎水性カプセルの作製2018

    • Author(s)
      武井 孝行
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 界面科学ならびに遠心技術を利用した気相中でのミリカプセルの構造制御2018

    • Author(s)
      武井 孝行、迫口 翔吾、大角 義浩、吉田 昌弘
    • Organizer
      久米島ワークショップ
    • Related Report
      2018 Research-status Report
  • [Book] 次世代のポリマー・高分子開発、新しい用途展開と将来展望2019

    • Author(s)
      武井 孝行、吉田 昌弘
    • Total Pages
      5
    • Publisher
      技術情報協会
    • ISBN
      9784861047381
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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