Nanobio antifungal agent for fungal pandemics
| Project/Area Number |
18K04842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 27040:Biofunction and bioprocess engineering-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | タンパク質工学 / 無機ナノ粒子 / 酵素 / 表面提示 / キチナーゼ活性 / 抗菌活性 / クラスター化 / インターフェイス / 銀ナノ粒子 / キチナーゼ / 高密度提示 / 高活性化 / 安定化 / 酵素ライブラリー / 抗真菌剤 / ワンポット合成 |
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| Outline of Final Research Achievements |
Japanese mold (Candida aureas) has become poisonous overseas, causing the first mycotic pandemic (global epidemic) in Europe, the United States and Asia.The development of antifungal agents with a new mechanism of action that is difficult to have resistance is expected.In this study, we have developed a nanobio antifungal agent that exhibits antifungal activity by using the natural antifungal enzyme chitinase on the surface of silver nanoparticles that have high antifungal activity and are less likely to develop resistance.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的意義は、全く異なる安定性や機能、および反応環境を有する無機ナノ粒子とタンパク質という2種の物質の融合研究である。両方の性質を十分に活かす最適条件と構造を開発することで波及効果を見込む。
社会的意義については、耐性を持ちやすい真菌症のパンデミックに対抗する手段として新たな作用機序の抗真菌剤を開発し社会に貢献する。
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Report
(4 results)
Research Products
(21 results)
