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Creation of novel artificial cells consisting of non-natural synthetic polymers

Research Project

Project/Area Number 18K04863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 28010:Nanometer-scale chemistry-related
Research InstitutionToyohashi University of Technology

Principal Investigator

Yoshida Eri  豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (60263175)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords人工細胞モデル / 高分子ジャイアントベシクル / 生体膜 / 自己組織化 / 両親媒性ジブロック共重合体 / 光精密リビングラジカル重合 / 重合誘導型自己組織化 / 人工生命 / 人工細胞膜モデル / 赤血球 / 感熱応答挙動 / 形態変化 / オートファジー融離膜 / 高分子ベシクル / 出芽 / 神経細胞 / 両親媒性ブロック共重合体 / 精密リビングラジカル重合 / ジャイアントベシクル / ベシクル膜 / 反応性結合部位 / 人工核膜モデル / 有窓ベシクル / 出芽分離 / 形態安定性 / ベシクル輸送 / 増殖 / 合成高分子 / 臨界充填形 / 人工細胞 / 分子集合体
Outline of Final Research Achievements

With the aim of elucidating the possibility of artificial life employing non-natural compounds, this study investigated the creation of biomembrane morphologies and dynamic behaviors in synthetic polymer aggregates with similarity to cells in their structure. This investigation demonstrated that polymer giant vesicles, composed of amphiphilic diblock copolymers, could exhibit various cellular features such as the morphology of the nuclear envelope with numerous pores, neuron-like tubular extensions, erythrocyte-like morphological transformations, and the process of cup-like vesicle formation. These results highlight the potential of designing and self-assembling diblock copolymers to pave the way for the creation of artificial life using non-natural synthetic polymers.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、生物学をはじめ、高分子化学や有機合成化学、コロイド化学、超分子科学など、幅広い分野に人工生命創製の手がかりを与えるものであり、学術的研究の進歩と発展を促す。また、生命誕生の起源の解明を助ける。一方、単細胞生物であるバクテリアの人工モデルとして、その生産活動を利用したバイオ燃料開発への応用や、極限環境条件下で増殖する古細菌のモデルとして、極限環境に生息するバクテリアの工業的な利用にも役立つことから、産業の発展にも寄与する。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (7 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Book (3 results)

  • [Journal Article] Polymer nanoarchitectonics for synthetic vesicles with human erythrocyte-like morphology transformation2022

    • Author(s)
      Eri Yoshida
    • Journal Title

      Colloid Polym. Sci.

      Volume: 300 Issue: 5 Pages: 497-508

    • DOI

      10.1007/s00396-022-04958-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of cup-shaped vesicle formation using amphiphilic diblock copolymer2022

    • Author(s)
      Eri Yoshida
    • Journal Title

      OJPolym. Chem.

      Volume: 12 Issue: 02 Pages: 43-54

    • DOI

      10.4236/ojpchem.2022.122003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuron-like tubule extension of giant polymer vesicles2021

    • Author(s)
      Yoshida Eri
    • Journal Title

      Chemical Reports

      Volume: 3 Issue: 1 Pages: 195-202

    • DOI

      10.25082/cr.2021.01.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Giant vesicles of amphiphilic diblock copolymer with branched side chains2021

    • Author(s)
      Yoshida Eri
    • Journal Title

      Colloid and Surface Science

      Volume: 6(1) Issue: 1 Pages: 1-7

    • DOI

      10.11648/j.css.20210601.11

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of giant vesicles supporting hindered amine on their shells through photo living radical polymerization-induced self-assembly2020

    • Author(s)
      Yoshida Eri
    • Journal Title

      Journal of Dispersion Science and Technology

      Volume: 41 Issue: 5 Pages: 763-770

    • DOI

      10.1080/01932691.2019.1617163

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thermo-responsiveness of giant vesicles supporting hindered amines as reactive sites2020

    • Author(s)
      Yoshida Eri
    • Journal Title

      Colloid and Polymer Science

      Volume: 298 Issue: 9 Pages: 1205-1214

    • DOI

      10.1007/s00396-020-04697-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perforated vesicles composed of amphiphilic diblock copolymer: new artificial biomembrane model of nuclear envelope2019

    • Author(s)
      Yoshida Eri
    • Journal Title

      Soft Matter

      Volume: 15 Issue: 48 Pages: 9849-9857

    • DOI

      10.1039/c9sm01832h

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological stability of worm-like vesicles consisting of amphiphilic diblock copolymer against external stress2019

    • Author(s)
      Yoshida Eri
    • Journal Title

      Chemical Reports

      Volume: 1 Issue: 2 Pages: 102-107

    • DOI

      10.25082/cr.2019.02.006

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CO2-responsive behavior of polymer giant vesicles supporting hindered amine2019

    • Author(s)
      Yoshida Eri
    • Journal Title

      Colloid and Polymer Science

      Volume: 297 Issue: 4 Pages: 661-666

    • DOI

      10.1007/s00396-019-04484-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation of giant vesicles containing quaternary ammonium salt of 2-(dimethylamino)ethyl methacrylate through photo nitroxide-mediated controlled/living radical polymerization-induced self-assembly2018

    • Author(s)
      Eri Yoshida
    • Journal Title

      J. Polym. Res.

      Volume: 25(5), 109 Issue: 5 Pages: 1-12

    • DOI

      10.1007/s10965-018-1509-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photo nitroxide-mediated living radical polymerization of hindered amine-supported methacrylate2018

    • Author(s)
      Eri Yoshida
    • Journal Title

      J. Res. Update Polym. Sci.

      Volume: 7(2) Issue: 2 Pages: 21-28

    • DOI

      10.6000/1929-5995.2018.07.02.1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Polymer giant vesicles as artificial models for dynamic biomembranes2023

    • Author(s)
      Eri Yoshida
    • Organizer
      ACS Spring 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 安定ラジカルによる光制御リビングラジカル重合と高分子設計2022

    • Author(s)
      Eri Yoshida
    • Organizer
      フォトポリマー懇話会 249回講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Polymer giant vesicles as artificial models of biomembrane2019

    • Author(s)
      Yoshida Eri
    • Organizer
      Annual Congress on Smart Materials 2019 (Prague, Czech Republic)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Artificial biomembrane models using giant vesicles prepared by photo NMP-induced self-assembly2019

    • Author(s)
      Yoshida Eri
    • Organizer
      The Polymerization-Induced Nanostructural Transitions symposium at the 258th American Chemical Society Fall National Meeting (San Diego, USA)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Artificial biomembrane models using polymer giant vesicles consisting of amphiphilic diblock copolymers2019

    • Author(s)
      Yoshida Eri
    • Organizer
      Global Biopolymers & Polymer Chemistry Congress (Las Vegas, USA)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Worm-like vesicles prepared by photo nitroxide-mediated controlled/living radical polymerization-induced self-assembly2018

    • Author(s)
      Eri Yoshida
    • Organizer
      4th International Conference on Polymer Chemistry (Stockholm, Sweden)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ワーム状ベシクルの形成と刺激に対する構造安定性2018

    • Author(s)
      吉田絵里
    • Organizer
      第69回コロイドおよび界面化学討論会
    • Related Report
      2018 Research-status Report
  • [Book] ラジカル重合を中心としたポリマー・微粒子・コーティング材の合成,応用,トラブル対策2020

    • Author(s)
      共著
    • Total Pages
      658
    • Publisher
      技術情報協会
    • ISBN
      9784861047763
    • Related Report
      2019 Research-status Report
  • [Book] 光機能性有機・高分子材料における新たな息吹2019

    • Author(s)
      市村國宏 監修(共著)
    • Total Pages
      333
    • Publisher
      シーエムシー出版
    • ISBN
      9784781314143
    • Related Report
      2019 Research-status Report
  • [Book] リビングラジカル重合―機能性高分子の合成と応用展開―(第II編 第11章 光精密ラジカル重合を用いる高分子の設計と合成)2018

    • Author(s)
      松本章一監修(共著)
    • Total Pages
      328
    • Publisher
      シーエムシー出版
    • ISBN
      9784781313368
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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