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Study on dynamic nuclear polarization using photo-excited triplet electron spins for versatile NMR spectroscopy

Research Project

Project/Area Number 18K05033
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 32010:Fundamental physical chemistry-related
Research InstitutionOsaka University

Principal Investigator

Akinori Kagawa  大阪大学, 基礎工学研究科, 助教 (70533701)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords動的核偏極 / 核磁気共鳴 / 電子スピン共鳴 / 光励起三重項状態 / 三重項状態 / 光励起
Outline of Final Research Achievements

We studied the generalization of dynamic nuclear polarization using electron spins in the photo-excited triplet state (triplet DNP) for NMR application. To evaluate its electron spin properties, an electron spin resonance spectrometer was developed. We also prepared a liquid NMR probe capable of measurement in a high magnetic field and a highly uniform magnetic field to show that triplet DNP can be used for chemical analysis applications. We have succeeded in increasing the number of molecular species that can be highly polarized by triplet DNP using eutectic, which is a new sample preparation method. Rose bengal was adopted as a new highly polarization source, but we did not measure electron spin signals at near liquid nitrogen temperature.

Academic Significance and Societal Importance of the Research Achievements

核磁気共鳴は、原子核のもつミクロな磁石の性質を利用し物質内部の情報を非破壊、非侵襲で測定できる有力な分光法である。応用幅も広く、化学解析、MRI、創薬、食料など多岐にわたっている。その最大の欠点である低感度を改善する手法が動的核偏極であり、その中でも光励起三重項状態を用いれば極低温、高磁場を必要としない動的核偏極が実現でき、安価な装置でのNMR応用が期待できる。本研究では、光励起三重項状態を用いた動的核偏極における装置開発、試料作製法、分子探索を行いNMR応用への汎用化を行った。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019 2018 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] High-field NMR with dissolution triplet-DNP2019

    • Author(s)
      Akinori Kagawa, Koichiro Miyanishi, Naoki Ichijo, Makoto Negoro, Yushi Nakamura, Hideo Enozawa, Tsuyoshi Murata, Yasushi Morita, Masahiro Kitagawa
    • Journal Title

      Journal of Magnetic Resonance

      Volume: 309 Pages: 106623-106623

    • DOI

      10.1016/j.jmr.2019.106623

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic Nuclear Polarization using Photoexcited Triplet Electron Spins in Eutectic Mixtures2018

    • Author(s)
      Akinori Kagawa, Makoto Negoro, Ryohei Ohba, Naoki Ichijo, Kota Takamine, Yushi Nakamura, Tsuyoshi Murata, Yasushi Morita, and Masahiro Kitagawa
    • Journal Title

      J. Phys. Chem. A

      Volume: 122 Issue: 50 Pages: 9670-9675

    • DOI

      10.1021/acs.jpca.8b09934

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] DNP using photo-excited triplet electron spins2021

    • Author(s)
      Akinori Kagawa
    • Organizer
      Intercontinental Magnetic Resonance Conference on Methods and Applications ICONS-Discussions
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 核スピンの高偏極化とその応用2020

    • Author(s)
      香川晃徳
    • Organizer
      186委員会第35回研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] トリプレットDNPによる高感度NMR2019

    • Author(s)
      香川 晃徳・根来 誠・一条 直規・宮西 考一郎・大庭 椋平・北川 勝浩・江野澤 英穂・中村 祐士・村田 剛志・森田 靖
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 高磁場における溶解トリプレットDNP実験2019

    • Author(s)
      宮西孝一郎, 一条直規, 本山誠, 香川晃徳, 根来誠, 中村祐士, 江野澤英穂, 村田剛志, 森 田靖, 北川勝浩
    • Organizer
      第58回NMR討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Instrumentation for room-temperature hyperpolarization NMR2019

    • Author(s)
      A. Kagawa, K. Miyanishi, N. Ichijo, M. Negoro, H. Enozawa, T. Murata, Y. Morita, M. Kitagawa
    • Organizer
      日米欧量子科学技術国際シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] トリプレットDNPに基づく高感度生体NMR/MRIのための核スピンセンサーの開発2019

    • Author(s)
      江野澤英穂、中村祐士、一条直規、根来 誠、香川晃徳、北川勝浩、村田剛志、森田靖
    • Organizer
      日本化学会第98春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 時間分解ESRによる多結晶中のペンタセンの光励起三重項状態のホスト分子、磁場依存性の研究2018

    • Author(s)
      鷹峰洸太、一条直規、根来誠、香川晃徳、北川勝浩
    • Organizer
      第57回電子スピンサイエンス学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] トリプレットDNPによる超高感度NMR/MRI2018

    • Author(s)
      香川晃徳
    • Organizer
      新世代研究所水和ナノ構造研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 光励起三重項状態を用いた動的核偏極による安息香酸との混合物の高偏極化2018

    • Author(s)
      大庭椋平、香川晃徳、根来誠、一条直規、北川勝浩、中村祐士、江野澤英穂、長田幸司、村田剛志、森田靖
    • Organizer
      第64回 固体NMR・材料フォーラム
    • Related Report
      2018 Research-status Report
  • [Presentation] Room temperature hyperpolarization of equal mixtures of benzoic acid and other aromatic carboxylic acid2018

    • Author(s)
      Akinori Kagawa, Makoto Negoro, Ryohei Ohba, Yushi Nakamura, Hideo Enozawa, Koji Osada, Tsuyoshi Murata, Yasushi Morita, Masahiro Kitagawa
    • Organizer
      Hyp18
    • Related Report
      2018 Research-status Report
  • [Remarks]

    • URL

      http://www.qc.ee.es.osaka-u.ac.jp/research_init_e.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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