Quantitative detection of chirality by chiral mass spectrometry on the basis of molecular recognition chemistry
| Project/Area Number |
18K05095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 33010:Structural organic chemistry and physical organic chemistry-related
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| Research Institution | Osaka Research Institute of Industrial Science and Technology |
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Principal Investigator |
Shizuma Motohiro 地方独立行政法人大阪産業技術研究所, 森之宮センター, 総括研究員 (40416318)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | キラリティー / 質量分析 / 分子認識 / 安定同位体標識 / 光学純度決定 |
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| Outline of Final Research Achievements |
The purpose of this study is chiral analysis by mass spectrometry only. In this study, chiral polyether hosts and chiral copper complexes were designed and synthesized to discrimine the chirality of chiral ammnonium ions and amino acids, respectively. Further, their enantiomer hosts labeled with deuterium atoms were synthesized. The pair of the labeled/unlabeled host were used after adding the guest mixture to estimate the enantiomeric excess of the multiple guests simultaneously, easily and quickly based on the relative peak intensity of the labeled/unlabeled host-guest complex ions by mass spectrometry only.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、生体内のD-アミノ酸がさまざまな疾病と関連していることやあるいは有用な作用をしていることなどが見いだされており、高感度で簡便なキラル評価方法が希求されている。本研究成果はこれらに対して高感度分析法である質量分析のみで迅速にキラル評価を行える手法を提案できた。また、分子間の相互作用およびイオン化部位の制御により質量分析でキラル評価ができるホスト-ゲスト系の分子設計について一つの指針を見出すことができた。
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Report
(4 results)
Research Products
(10 results)
