| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Palladium enolates, which commonly act as nucleophiles, are known to react with an electrophile. We have succeeded in the development of new catalytic reactions involving nucleophilic interception of the palladium enolate. This umpolung process furnishes an efficient route to densely functionalized carbonyl compounds by way of ring-closing carbon-carbon bond formation and subsequent nucleophilic attack at the resulting palladium enolate intermediate. It is also revealed that fine-tuning of the electron density on the palladium complex is crucial for this enolate umpolung process.
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