| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Because carbon-fluorine bonds are stable bonds, it has been difficult to carry out chemical transformations while cleaving them. In contrast, focusing on fluorine elimination using metals and HF elimination using acids, I developed a C-F bond activation method under mild reaction conditions.
By using fluoroalkenes as substrates, metal-mediated β-fluorine elimination was combined with oxidative cyclization, nucleophilic addition, or metalacyclopropanation to produce high-value-added fluorine-containing heterocyclic compounds.
Furthermore, an intremorecular C-F/C-H coupling was achieved by HF elimination followed by electrophilic addition on treatment of fluoroarenes with arenes in the presence of an appropriate acid.
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