| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
An asymmetric Diels-Alder reaction of 2,4-dienols and methyl acrylate utilizing a chiral Zn(II)/Mg(II) bimetallic template with low catalyst loading is successfully achieved. The bimetallic Lewis acid template derived from H8-BINOL catalyzed the Diels-Alder reaction in the presence of MS-4A to afford various functionalized bicyclic lactones with high enantiomeric purities. The bimetallic Lewis acid-template Diels-Alder reaction is feasible to hetero-Diels-Alder reaction of 4-siloxy-2,4-penta-dienols and aldehydes to provide substituted dihydropyrans with good enantioselectivities. The synthetic application for biologically active compound such as exiguolide was also investigated.
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