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Development of Hybrid Metal Complexes of Natural Product-derived Dyes Having Tumor Targeting Ability for the Next- Generation Advanced Medical Care

Research Project

Project/Area Number 18K05161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 34010:Inorganic/coordination chemistry-related
Research InstitutionNara Women's University

Principal Investigator

Yano Shigenobu  奈良女子大学, 大和・紀伊半島学研究所, 協力研究員 (60011186)

Co-Investigator(Kenkyū-buntansha) 片岡 洋望  名古屋市立大学, 医薬学総合研究院(医学), 教授 (40381785)
野元 昭宏  大阪府立大学, 工学(系)研究科(研究院), 准教授 (60405347)
鳴海 敦  山形大学, 大学院有機材料システム研究科, 教授 (60443975)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords医療 / 光線力学療法 / 光増感剤 / 生命系色素 / 糖 / 金属錯体 / 医工連携 / 錯体 / 光線力学診断 / 糖鎖
Outline of Final Research Achievements

In Japan, which is facing an aging society, the development of minimally invasive medical care with less burden on patients is strongly desired. We have succeeded in synthesis and characterization of sugar-conjugated photo sensitizers having tumor targeting ability for photodynamic therapy which might be available for next-generation advanced medical care.

Academic Significance and Societal Importance of the Research Achievements

我が国では、高齢化社会の進展に伴い、癌患者数が増加の一途を辿っており、低侵襲性の、QOL の低下を招かない癌治療が切望されている。光線力学療法 (Photodynamic Therapy: PDT)とは、癌細胞内部に光感受性物質を集積させ、これに特定波長の光線を照射し、それにより惹起する活性酸素で癌細胞を選択的に破壊する治療法である。本研究では PDT 用の新規光増感剤を開発した。それらの機能評価の結果、次世代先端医療用としての実用展開が期待される高性能な化合物であることが明らかとなり、極めて意義深い結果が得られた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020 2019 2018

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] Photodynamic therapy using mannose-conjugated chlorin e6 increases cell surface calreticulin in cancer cells and promotes macrophage phagocytosis2022

    • Author(s)
      Kimura Yuka、Aoki Hiromasa、Soyama Tatsuki、Sakuragi Akira、Otsuka Yuto、Nomoto Akihiro、Yano Shigenobu、Nishie Hirotada、Kataoka Hiromi、Aoyama Mineyoshi
    • Journal Title

      Medical Oncology

      Volume: 39 Issue: 6 Pages: 82-82

    • DOI

      10.1007/s12032-022-01674-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential of Photodynamic Therapy Based on Sugar-Conjugated Photosensitizers2021

    • Author(s)
      Kataoka Hiromi、Nishie Hirotada、Tanaka Mamoru、Sasaki Makiko、Nomoto Akihiro、Osaki Tomohiro、Okamoto Yoshiharu、Yano Shigenobu
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 4 Pages: 841-841

    • DOI

      10.3390/jcm10040841

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] LARGE-SCALE SYNTHESIS OF THIO-GLUCOSE-CONJUGATED CHLORIN E6 FOR PHOTODYNAMIC THERAPY2021

    • Author(s)
      A. Nomoto, H. Yamaguchi, M. Masuda, K. Hyakumura, S. Kodama, T. Osaki, Y. Okamoto, M. Tanaka, H. Kataoka, A. Narumi, T. Yoshimura, S. Yano, A. Ogawa
    • Journal Title

      HETEROCYCLES

      Volume: 103 Pages: 2021-2027

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maltotriose?Chlorin e6 Conjugate Linked via Tetraethyleneglycol as an Advanced Photosensitizer for Photodynamic Therapy. Synthesis and Antitumor Activities against Canine and Mouse Mammary Carcinoma Cells2021

    • Author(s)
      Narumi Atsushi、Rachi Rioko、Yamazaki Hiromi、Kawaguchi Seigou、Kikuchi Moriya、Konno Hiroyuki、Osaki Tomohiro、Okamoto Yoshiharu、Shen Xiande、Kakuchi Toyoji、Kataoka Hiromi、Nomoto Akihiro、Yoshimura Tomokazu、Yano Shigenobu
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 10 Pages: 7023-7033

    • DOI

      10.1021/acsomega.0c06316

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Photodynamic therapy exploiting the anti-tumor activity of mannose-conjugated chlorin e6 reduced M2-like tumor-associated macrophages2021

    • Author(s)
      Soyama Tatsuki、Sakuragi Akira、Oishi Daisuke、Kimura Yuka、Aoki Hiromasa、Nomoto Akihiro、Yano Shigenobu、Nishie Hirotada、Kataoka Hiromi、Aoyama Mineyoshi
    • Journal Title

      Translational Oncology

      Volume: 14 Issue: 2 Pages: 101005-101005

    • DOI

      10.1016/j.tranon.2020.101005

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel photosensitizer β-mannose-conjugated chlorin e6 as a potent anticancer agent for human glioblastoma u251 cells2020

    • Author(s)
      Shinoda Yo、Kujirai Kohei、Aoki Kohei、Morita Mai、Masuda Masato、Zhang Lihao、Kaixin Zhou、Nomoto Akihiro、Takahashi Tsutomu、Tsuneoka Yayoi、Akimoto Jiro、Kataoka Hiromi、Rachi Rioko、Narumi Atsushi、Yoshimura Tomokazu、Yano Shigenobu、Fujiwara Yasuyuki
    • Journal Title

      Pharmaceuticals

      Volume: 13 Issue: 10 Pages: 1

    • DOI

      10.3390/ph13100316

    • URL

      https://pure.teikyo.jp/en/publications/10174cd0-7189-4337-9465-740ccbba6e1a

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Basic Study of Photodynamic Therapy with Glucose-Conjugated Chlorin e6 Using Mammary Carcinoma Xenografts2019

    • Author(s)
      Osaki Tomohiro、Hibino Shota、Yokoe Inoru、Yamaguchi Hiroaki、Nomoto Akihiro、Yano Shigenobu、Mikata Yuji、Tanaka Mamoru、Kataoka Hiromi、Okamoto Yoshiharu
    • Journal Title

      Cancers

      Volume: 11 Issue: 5 Pages: 636-636

    • DOI

      10.3390/cancers11050636

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] C60 Fullerene with Tetraethylene Glycols as a Well-defined Soluble Building Block and Saccharide-conjugation Producing PDT Photosensitizer2019

    • Author(s)
      Narumi Atsushi、Nakazawa Tatsufumi、Shinohara Kosuke、Kato Hiroki、Iwaki Yoshinori、Okimoto Haruya、Kikuchi Moriya、Kawaguchi Seigou、Hino Shodai、Ikeda Atsushi、Shaykoon Montaser Shaykoon Ahmed、Shen Xiande、Duan Qian、Kakuchi Toyoji、Yasuhara Kazuma、Nomoto Akihiro、Mikata Yuji、Yano Shigenobu
    • Journal Title

      Chemistry Letters

      Volume: 48 Issue: 10 Pages: 1209-1212

    • DOI

      10.1246/cl.190492

    • NAID

      130007724085

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antitumor Effect of a Novel Photodynamic Therapy With Acetylated Glucose-conjugated Chlorin for Gastrointestinal Cancers2019

    • Author(s)
      ICHIKAWA HIROSHI、NISHIE HIROTADA、YANO SHIGENOBU、KOMAI YUKI、YAMAGUCHI HIROAKI、NOMOTO AKIHIRO、SUZUKI TAKETO、TANAKA MAMORU、SHIMURA TAKAYA、MIZOSHITA TSUTOMU、KUBOTA EIJI、TANIDA SATOSHI、KATAOKA HIROMI
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 8 Pages: 4199-4206

    • DOI

      10.21873/anticanres.13580

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 次世代糖連結金属錯体抗がん剤の開発を目指して2022

    • Author(s)
      矢野重信、舩橋 靖博、野元 昭宏、中井 美早紀
    • Organizer
      日本薬学第142回年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Development of the advanced next-generation glycoconjugated photosennseiteizers for photodynamic therapy2021

    • Author(s)
      Yano, Shigenobu; Kataoka, Hiromi; Osaki, Tmohiro; Okamoto, Yoshiharu; Nomoto, Akihiro; Rachi, Rioko; Narumi, Atsushi; Aoki, Kohei; Kujirai, Kohei; Shinoda, YO; Fujiwara, Yasuyuki; Morimoto, keiko.
    • Organizer
      Pacifichem 2021 Congress
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Development of the advanced next-generation glycoconjugated photosensitizers for photodynamic therapy2021

    • Author(s)
      Yano, Shigenobu; Kataoka, Hiromi; Osaki, Tmohiro; Okamoto, Yoshiharu; Nomoto, Akihiro; Rachi, Rioko; Narumi, Atsushi; Aoki, Kohei; Kujirai, Kohei; Shinoda, YO; Fujiwara, Yasuyuki; Morimoto, Keiko.
    • Organizer
      Pacifichem 2021 Congress
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 新規抗がん剤の創生を目指した糖含有三座配位子銅錯体の合成および生物学的活性2021

    • Author(s)
      田中 沙樹、ロレンツォ デ ベラ アルバ、畑中 翼、矢島辰雄、鯨井 康平、勝 澤 拓実、篠田 陽、藤原 泰之、中井 美早紀、矢野 重信、舩橋 靖博
    • Organizer
      日本化学会 第101春季年会 (2021)
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗がん性のある糖連結パラジウム錯体の生理条件下での挙動2021

    • Author(s)
      吉田 歩未、ロレンツォ デ ベラ アルバ、畑中 翼、野元 昭宏、中井 美早紀、矢野 重信、舩橋 靖博
    • Organizer
      日本化学会 第101春季年会 (2021)
    • Related Report
      2020 Research-status Report
  • [Presentation] 糖含有三座Schiff塩基-銅錯体のヒト悪性髄膜腫HKBMM細胞に対する抗がん活性2020

    • Author(s)
      篠田 陽,勝澤 拓実,鯨井 康平,田中 沙樹,ロレンツォ デ ベラ アルバ,畑中 翼,中井 美早紀,矢野 重信,船橋 靖博,藤原 泰之
    • Organizer
      メタルバイオサイエンス研究会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 糖連結光感受性薬剤を用いた光線力学療法の前臨床試験2020

    • Author(s)
      片岡洋望,田中 守,西江裕忠,佐々木槇子,大崎智弘,岡本芳晴,野元昭宏,矢野重信
    • Organizer
      LASER WEEK IN KOCHI
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 小動物腫瘍に対する光線力学療法の試み2020

    • Author(s)
      大崎智弘、石塚昌宏、田中 徹、阪田 功、野元昭宏、矢野重信、片岡洋望、岡本芳晴
    • Organizer
      LASER WEEK IN KOCHI
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 新規抗がん剤の創製を目指した糖含有三座Schiff塩基-銅錯体の合成2020

    • Author(s)
      田中沙樹、ロレンツォ デ ベラ アルバ、畑中 翼、鯨井康平、勝澤拓実、篠田陽、藤原泰之、中井美早紀、矢野重信、舩橋靖博
    • Organizer
      錯体化学会第70回討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] マルトトリオース/クロリンe6複合体・PDT光増感剤の合成と光細胞毒性2020

    • Author(s)
      良知里緒子、大崎智弘、野元昭宏、矢野重信、鳴海敦
    • Organizer
      2020高分子学会東北支部発表会
    • Related Report
      2020 Research-status Report
  • [Presentation] 腫瘍関連マクロファージ(TAM)を標的とした光線力学療法(PDT)によるがんの治療2020

    • Author(s)
      木村優花、曽山樹、櫻木章、大石大祐、青木啓将、西江裕忠、野元昭宏、矢野重信、片岡洋望、青山峰芳
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of glyco-conjugated chlorin e6 for photodynamic therapy2019

    • Author(s)
      Shigenobu Yano, Hiromi Kataoka, Akihiro Nomoto, Tomohiro Osaki, Yoshiharu Okamoto
    • Organizer
      3.Experimental Biology 2019 (Orland,Florida,USA)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Antitumor activity of Polypyridine Co(III) complexes against Hypoxia tumor and their solution reaction with ascorbic acid2019

    • Author(s)
      Misaki Nakai, Yusuke shimonaka, Akitsugu Hayashi, Shigenobu Yano, Akihiro Nomoto, Akiya Ogawa, Yasuo Nakabayashi
    • Organizer
      19th International Conference on Biological Inorganic Chemistry (Interlaken, Switzerland)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sugar-linked chlorin e6 for photodynamic therapy2019

    • Author(s)
      Shigenobu Yano、 Hiromi.Kataoka、 Mamoru Tanaka、 Hirotada Nishie、 Tomohiro.Osaki、 Yoshiharu Okamoto、 Akihiro Nomoto
    • Organizer
      The 26th International SPACC Symposium (Glasgow, Scotland, UK)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 医工連携による光線力学療法用次世代糖連結光感受性物質の開発2019

    • Author(s)
      矢野重信
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 小動物腫瘍に対する光線力学療法2019

    • Author(s)
      大崎智弘,石塚昌宏,田中 徹,阪田 功,野元昭宏,矢野重信,片岡洋望,岡本芳晴
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 光線力学療法のためのクロリンe6エステルへの糖鎖導入反応の検討2019

    • Author(s)
      増田理人,野元昭宏,矢野重信,小川昭弥
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腫瘍選択的光線力学療法のためのクロリン誘導体の合成および評価2018

    • Author(s)
      山口浩明,野元昭宏,片岡洋望,矢野重信
    • Organizer
      第45回有機典型元素化学討論会
    • Related Report
      2018 Research-status Report
  • [Book] 錯体化合物事典2019

    • Author(s)
      矢野重信(分担執筆)
    • Total Pages
      10
    • Publisher
      朝倉書店
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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