Development of Hybrid Metal Complexes of Natural Product-derived Dyes Having Tumor Targeting Ability for the Next- Generation Advanced Medical Care
| Project/Area Number |
18K05161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Nara Women's University |
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Principal Investigator |
Yano Shigenobu 奈良女子大学, 大和・紀伊半島学研究所, 協力研究員 (60011186)
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| Co-Investigator(Kenkyū-buntansha) |
片岡 洋望 名古屋市立大学, 医薬学総合研究院(医学), 教授 (40381785)
野元 昭宏 大阪府立大学, 工学(系)研究科(研究院), 准教授 (60405347)
鳴海 敦 山形大学, 大学院有機材料システム研究科, 教授 (60443975)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 医療 / 光線力学療法 / 光増感剤 / 生命系色素 / 糖 / 金属錯体 / 医工連携 / 錯体 / 光線力学診断 / 糖鎖 |
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| Outline of Final Research Achievements |
In Japan, which is facing an aging society, the development of minimally invasive medical care with less burden on patients is strongly desired. We have succeeded in synthesis and characterization of sugar-conjugated photo sensitizers having tumor targeting ability for photodynamic therapy which might be available for next-generation advanced medical care.
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| Academic Significance and Societal Importance of the Research Achievements |
我が国では、高齢化社会の進展に伴い、癌患者数が増加の一途を辿っており、低侵襲性の、QOL の低下を招かない癌治療が切望されている。光線力学療法 (Photodynamic Therapy: PDT)とは、癌細胞内部に光感受性物質を集積させ、これに特定波長の光線を照射し、それにより惹起する活性酸素で癌細胞を選択的に破壊する治療法である。本研究では PDT 用の新規光増感剤を開発した。それらの機能評価の結果、次世代先端医療用としての実用展開が期待される高性能な化合物であることが明らかとなり、極めて意義深い結果が得られた。
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] LARGE-SCALE SYNTHESIS OF THIO-GLUCOSE-CONJUGATED CHLORIN E6 FOR PHOTODYNAMIC THERAPY2021
Author(s)
A. Nomoto, H. Yamaguchi, M. Masuda, K. Hyakumura, S. Kodama, T. Osaki, Y. Okamoto, M. Tanaka, H. Kataoka, A. Narumi, T. Yoshimura, S. Yano, A. Ogawa
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Journal Title
HETEROCYCLES
Volume: 103
Pages: 2021-2027
Related Report
Peer Reviewed
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[Presentation] Development of the advanced next-generation glycoconjugated photosennseiteizers for photodynamic therapy2021
Author(s)
Yano, Shigenobu; Kataoka, Hiromi; Osaki, Tmohiro; Okamoto, Yoshiharu; Nomoto, Akihiro; Rachi, Rioko; Narumi, Atsushi; Aoki, Kohei; Kujirai, Kohei; Shinoda, YO; Fujiwara, Yasuyuki; Morimoto, keiko.
Organizer
Pacifichem 2021 Congress
Related Report
Invited
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[Presentation] Development of the advanced next-generation glycoconjugated photosensitizers for photodynamic therapy2021
Author(s)
Yano, Shigenobu; Kataoka, Hiromi; Osaki, Tmohiro; Okamoto, Yoshiharu; Nomoto, Akihiro; Rachi, Rioko; Narumi, Atsushi; Aoki, Kohei; Kujirai, Kohei; Shinoda, YO; Fujiwara, Yasuyuki; Morimoto, Keiko.
Organizer
Pacifichem 2021 Congress
Related Report
Invited
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