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Control of Hydration States of Charged Polymer Thin Films and Visualization of the Interactions

Research Project

Project/Area Number 18K05218
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 35010:Polymer chemistry-related
Research InstitutionOita University

Principal Investigator

Higaki Yuji  大分大学, 理工学部, 准教授 (40619649)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords荷電高分子 / 高分子電解質 / 双性イオン高分子 / 水和状態 / 分子間相互作用 / 生体適合性 / 潤滑性 / 薄膜 / イオン / 中性子反射率測定 / 反射干渉顕微鏡 / ポリマーブラシ
Outline of Final Research Achievements

Hydration state of charged polymer thin films and the interactions with biomolecules were investigated by neutron reflectivity and particle fluctuation analysis through reflective interference contrast microscopy. We showed that the charged polymer thin films exhibit modulation of the hydration state and interactions with biomolecules depending on the chemical structure of the charged polymers as well as the interactions with co-existing ions, solvents, and/or biomolecules. Also, hybrid thin films with excellent lubrication under wet conditions were developed through the conjugation of charged polymer thin films and biomolecules.

Academic Significance and Societal Importance of the Research Achievements

湿潤環境下における荷電高分子薄膜の水和状態や相互作用は、その計測が技術的に困難であるため未だ解明されていない。本研究における荷電高分子の水和状態と相互作用の環境応答性についての知見は、荷電高分子の生体適合性や潤滑性における普遍的原理の解明につながる研究成果である。荷電高分子は、人工血管、人工関節、ステントなどの医用材料に幅広く用いられており、その生体適合性、潤滑性の起源は高性能バイオマテリアルの開発を促す学術的知見となる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (3 results)

  • [Int'l Joint Research] University of Heidelberg(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Heidelberg(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Hydration State Variation of Polyzwitterion Brushes through Interplay with Ions2020

    • Author(s)
      Yuji Higaki, Motoyasu Koayashi, Atsushi Takahara
    • Journal Title

      Langmuir

      Volume: 36 Issue: 31 Pages: 9015-9024

    • DOI

      10.1021/acs.langmuir.0c01672

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cationic Polymer Brush/Giant Polysaccharide Sacran Assembly: Structure and Lubricity2020

    • Author(s)
      Kosuke Igata, Tatsunori Sakamaki, Yoshihiro Inutsuka, Yuji Higaki, Maiko K. Okajima, Norifumi L. Yamada, Tatsuo Kaneko, Atsushi Takahara
    • Journal Title

      Langmuir

      Volume: ー Issue: 23 Pages: 6494-6501

    • DOI

      10.1021/acs.langmuir.0c00854

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ion-Specific Hydration States of Zwitterionic Poly(sulfobetaine methacrylate) Brushes in Aqueous Solutions2018

    • Author(s)
      Sakamaki Tatsunori、Inutsuka Yoshihiro、Igata Kosuke、Higaki Keiko、Yamada Norifumi L.、Higaki Yuji、Takahara Atsushi
    • Journal Title

      Langmuir

      Volume: 35 Issue: 5 Pages: 1583-1589

    • DOI

      10.1021/acs.langmuir.8b03104

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 双性イオン高分子の界面構造と相互作用の可視化2020

    • Author(s)
      檜垣勇次
    • Organizer
      高分子学会・中国四国支部 高分子研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] イオン選択的ポリスルホベタインブラシ薄膜水和状態と表面張力2019

    • Author(s)
      檜垣勇次、坂巻達記、井形航維、伊原大貴、山田悟史、高原 淳
    • Organizer
      第68回 高分子学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Hydration State and Interaction Potential of Zwitterionic Poly(sulfobetaine) Brushes in Aqueous Solutions2019

    • Author(s)
      Yuji Higaki
    • Organizer
      2019 Pusan-Gyeongnam/Kyushu-Seibu Joint Symposium on High Polymers(19th) and Fibers(17th)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Counter Anion-Specific Hydration States of Poly(quarternary ammonium cation) Brushes2018

    • Author(s)
      檜垣勇次、犬塚仁浩、坂巻達記、井形航維、池本夕佳、山田悟史、高原 淳
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ポリアンモニウムカチオンブラシ薄膜の対アニオン選択的水和膨潤と濡れ性2018

    • Author(s)
      檜垣勇次、犬塚仁浩、坂巻達記、井形航維、池本夕佳、山田悟史、高原 淳
    • Organizer
      平成30年度繊維学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] イオンとの相互作用によるポリスルホベタインブラシの油滴付着性変化2018

    • Author(s)
      檜垣勇次、坂巻達記、井形航維、山田悟史、高原 淳
    • Organizer
      第56回日本接着学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 荷電ポリマーブラシ薄膜の水和状態と界面特性2018

    • Author(s)
      檜垣勇次,高原 淳
    • Organizer
      北陸先端科学技術大学院大学 マテリアルサイエンス系セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Hydration State of Zwitterionic Polymer Brushes Depending on the Interactions with Ions and Charged Molecules2018

    • Author(s)
      Yuji Higaki, Tatsunori Sakamaki, Kosuke Igata, Daiki Ihara, Norifumi L. Yamada, Atsushi Takahara
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Research-status Report
  • [Remarks] 大分大学 檜垣研究室 Website

    • URL

      https://yuhigakki.wixsite.com/mysite

    • Related Report
      2020 Annual Research Report 2019 Research-status Report 2018 Research-status Report
  • [Remarks] 大分大学 研究者情報

    • URL

      http://oitauniv-soran.ad.oita-u.ac.jp/profile/ja.39408d0d4377b8c5520e17560c007669.html

    • Related Report
      2020 Annual Research Report 2019 Research-status Report 2018 Research-status Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/higaki_yuji/

    • Related Report
      2020 Annual Research Report 2019 Research-status Report 2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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