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Fabrication of high-toughness silk-fibers from regenerated silk proteins

Research Project

Project/Area Number 18K05250
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 35020:Polymer materials-related
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

YOSHIOKA TAIYO  国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 上級研究員 (90596165)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsシルク / 高タフネス繊維 / 階層構造 / X線構造解析 / 紡糸 / 構造制御 / 構造材料 / 持続可能社会 / 再生シルク / ナノフィブリル / 繊維構造 / 脱石油社会 / 構造解析 / 脱石油材料 / 高タフネス / 構造タンパク
Outline of Final Research Achievements

Silk, which is a renewable resource with excellent mechanical property, is attracting attention from the field of next-generation of structural materials. In order to realize mass production of silk, the creation of artificial silk protein is being promoted all over the world, and therefore the development of its spinning technology is urgently required. The purpose of this study is to develop the artificial spinning technology giving artificial silk fibers with comparable mechanical property with native silks. In this study, first, a detailed structural analysis for various silks was carried out and then the structural formation process was investigated. Finally, an artificial spinning system was developed by mimicking the structural formation mechanism learned from the native silks. The achievements in this study is expected to contribute to accelerate the realize of sustainable society.

Academic Significance and Societal Importance of the Research Achievements

持続可能社会の実現に向け、優れた力学特性を有する再生可能資源「シルク」が次世代構造材料の分野より注目を集めている。シルクの大量生産に向け、人工シルクタンパク質の創製が世界中で進められており、その紡糸技術の開発が急務とされている。本研究では、構造材料として実用化可能な力学特性を備える人工シルク繊維を紡糸するための技術開発を目的とした。本研究で得られた成果は、人工シルクタンパク質の紡糸技術としても応用可能であり、持続可能社会の構築、脱石油社会への実現など、SDGsに貢献する成果である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Hexagonal Packing of Nanofibrils in Bombyx mori Silkworm Silk Revealed by Small-angle X-ray Scattering Analysis2020

    • Author(s)
      Taiyo YOSHIOKA, Tsunenori KAMEDA
    • Journal Title

      The Journal of Silk Science and Technology of Japan

      Volume: 28 Pages: 129-135

    • NAID

      130007887007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptomic Analysis of the Bagworm Moth Silk Gland Reveals a Number of Silk Genes Conserved within Lepidoptera2020

    • Author(s)
      Takuya TSUBOTA, Taiyo YOSHIOKA, Akiya Jouraku, Takao K SUZUKI, Naoyuki YONEMURA, Kenji YUKUHIRO, Tsunenori KAMEDA, Hideki SEZUTSU
    • Journal Title

      Insect Science

      Volume: 0 Issue: 4 Pages: 1-16

    • DOI

      10.1111/1744-7917.12846

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 高タフネスシルクの階層構造:アミノ酸からフィブリル構造まで2020

    • Author(s)
      吉岡太陽
    • Journal Title

      繊維機械学会誌

      Volume: -

    • Related Report
      2020 Annual Research Report
  • [Journal Article] シルク繊維の高タフネス性発現機構に関する研究2020

    • Author(s)
      吉岡太陽
    • Journal Title

      繊維学会誌

      Volume: 76 Pages: 372-376

    • NAID

      130007922190

    • Related Report
      2020 Annual Research Report
  • [Journal Article] ミノムシの糸に学ぶ強くタフなシルク創製に向けたヒント2020

    • Author(s)
      吉岡太陽
    • Journal Title

      接着の技術誌

      Volume: 39 Pages: 14-17

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Hexagonal Packing of Nanofibrils in Bombyx mori Silkworm Silk Revealed by Small-angle X-ray Scattering Analysis2020

    • Author(s)
      Yoshioka Taiyo、Kameda Tsunenori
    • Journal Title

      J. Silk Sci. Tech. Jpn.

      Volume: 28

    • NAID

      130007887007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structure Water-Solubility Relationship in α-Helix-Rich Films Cast from Aqueous and 1,1,1,3,3,3-Hexafluoro-2-Propanol Solutions of S. c. ricini Silk Fibroin2019

    • Author(s)
      Moseti、Yoshioka、Kameda、Nakazawa
    • Journal Title

      Molecules

      Volume: 24 Issue: 21 Pages: 3945-3945

    • DOI

      10.3390/molecules24213945

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aggregation State of Residual α-Helices and Their Influence on Physical Properties of S. c. ricini Native Fiber2019

    • Author(s)
      Moseti Kelvin O.、Yoshioka Taiyo、Kameda Tsunenori、Nakazawa Yasumoto
    • Journal Title

      Molecules

      Volume: 24 Issue: 20 Pages: 3741-3741

    • DOI

      10.3390/molecules24203741

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A study of the extraordinarily strong and tough silk produced by bagworms2019

    • Author(s)
      Yoshioka Taiyo、Tsubota Takuya、Tashiro Kohji、Jouraku Akiya、Kameda Tsunenori
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1469-1469

    • DOI

      10.1038/s41467-019-09350-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] X-ray Scattering Analyses Quantitatively Revealed Periodic Hierarchical Structure of Polyalanine Beta-sheet and Non-polyalanine Amorphous Domains in Antheraea assamensis (Muga) Silk2019

    • Author(s)
      Yoshioka Taiyo、Kameda Tsunenori
    • Journal Title

      J. Silk Sci. Tech. Jpn.

      Volume: 27 Pages: 95-101

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] タフなシルクの階層構造:アミノ酸配列からフィブリル構造まで2020

    • Author(s)
      吉岡太陽
    • Organizer
      日本繊維機械学会関東支部講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シルク繊維の高タフネス性発現機構に関する研究2020

    • Author(s)
      吉岡太陽
    • Organizer
      2020年度繊維学会年次大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] シルクのナノフィブリル構造とその構造形成機構2020

    • Author(s)
      吉岡太陽, 亀田恒徳
    • Organizer
      2020年繊維学会秋季研究発表会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 放射光X線散乱法に基づくシルク・ナノフィブリル構造形成機構の追跡2020

    • Author(s)
      吉岡太陽, 亀田恒徳
    • Organizer
      第69回高分子討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ミノムシの糸の強さの解明2019

    • Author(s)
      吉岡太陽、亀田恒徳、坪田拓也、上樂明也、田代孝二
    • Organizer
      令和元年度繊維学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] A mild dissolution strategy for cocoon silk from the non-mulberry silkworm, Samia cynthia ricini.2019

    • Author(s)
      Kelvin O. Moseti, Taiyo YOSHIOKA, Tsunenori KAMEDA, Yasumoto NAKAZAWA
    • Organizer
      令和元年度繊維学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 強くタフなシルクを与えるアミノ酸配列の条件2019

    • Author(s)
      吉岡太陽、亀田恒徳
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ミノムシシルク2019

    • Author(s)
      吉岡太陽、亀田恒徳
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新しいシルク:ミノムシシルク!2019

    • Author(s)
      吉岡太陽、亀田恒徳、浅沼章宗
    • Organizer
      医工連携フォーラム2019
    • Related Report
      2018 Research-status Report
  • [Presentation] Relationships between protein amino acid sequence, hierarchical structure and mechanical deformation behaviour of Antheraea assamensis (Muga) silk2019

    • Author(s)
      Taiyo Yoshioka, Tsunenori Kameda
    • Organizer
      The 6th Asia-Pacific Congress of Sericulture and Insect Biotechnology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Strongest and toughest new silk: bagworm silk!2019

    • Author(s)
      Taiyo Yoshioka, Tsunenori Kameda
    • Organizer
      The 6th Asia-Pacific Congress of Sericulture and Insect Biotechnology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射光X線解析から分かってきたシルクの高タフネス発現における階層構造の役割2018

    • Author(s)
      吉岡太陽
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] シルクの力学特性における階層構造の役割2018

    • Author(s)
      吉岡太陽、亀田恒徳
    • Organizer
      平成30年度繊維学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Structural change and its effect on the mechanical property of silk induced by tensile deformation2018

    • Author(s)
      Taiyo Yoshioka, Tsunenori Kameda, Kohji Tashiro
    • Organizer
      The Fiber Society's Spring 2018 Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] カイコの科学2020

    • Author(s)
      吉岡太陽
    • Publisher
      朝倉書店
    • ISBN
      9784254420432
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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