| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Artificial DNA was synthesized by enzymatically generating reactive sites and binding cavity inside DNA and covalently introducing photofunctional molecules in a location-specific manner. DNA with thiazole orange (TO), a fluorescent dye, was prepared, and it was shown that the on-off and emission wavelength of the fluorescence could be controlled by the adjacent base sequence and the number of TO molecules. It is expected to be applied as a fluorescent nucleic acid sensor that enables molecular imaging.
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