| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This research aimed at the asymmetric total syntheses of Andrastin C and Brasilicardins A-D which belong to biologically active natural products with multiple quaternary asymmetric carbon atoms. To achieve this goal, new methods for stereoselective construction of a quaternary asymmetric carbon atom were developed by using an intramolecular conjugate addition of a cyano anion and an intramolecular cyano ene reaction. By using them as key reactions, we accomplished the asymmetric total syntheses of Brasilicardin A-D. In addition, we developed the stereoselective synthesis of the AB-ring and BCD-ring units of Andrastin C.
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