| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
Protein glycosylation is one of the most common post-translational modifications. N-linked and O-linked glycosylation are the most abundant types, in which sugar is attached to the side chain of asparagine and serine/threonine residues, respectively. In addition, S-linked glycosylation on cysteine residues has been recently known. In this study, a bacterial S-linked glycosyltransferase involved in biosynthesis of a peptide antibiotic was focused on for the purpose of understanding the reaction mechanism of S-glycosylation by the glycosyltransferase, and the crystal structure of the enzyme was successfully determined.
|
