| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Humanin is a peptide factor that ameliorates Alzheimer's disease-associated pathological events including cognitive dysfunction. We investigated physiological function of Humanin in the central nervous system. In normal young mice, Humanin increased the amounts of neurotransmitters in the hippocampus, the major brain region for memory formation, and improved cognitive activity. We also found that Humanin directly acted on neuronal cells and promoted neurotransmitter release. These findings suggest that Humanin regulates physiological activity of neurons, which help understand how Humanin maintains healthy cognitive function.
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