| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Reactive nitrogen species-induced neuronal cell death is known to be associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In the present study, we purified fungal secondary metabolites to construct a chemical library, and screened the chemical library for small molecules that protect from reactive nitrogen species-induced cell death. As a results, we discovered a novel neuroprotective compound, pestalotioquinol A. Pestalotioquinol A did not exhibit cytoprotective effect on reactive oxygen species-induced cell death, which suggested that cytoprotection of pestalotioquinol A is specific for reactive nitrogen species.
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