| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The study examined the effects of different toxic metals on root apical meristems using Arabidopsis as the model plant. We first optimized the agar plate conditions for the metal toxicity phenotyping. We then demonstrated that phenyl-mercury is detoxified through AtPCS1-mediated pathway as like inorganic-mercury. AtPCS1 is predominantly expressed in epidermal cells of the root, suggesting that the cell type plays a major role in detoxification of various toxic metals. In contrast, possible molecular targets of metal toxicity are likely to differ among metal species and chemical forms: among cell cycle and cell division disturbance was suggested and auxin distribution defect was suggested as its upstream target.
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