| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Coenzyme Q (CoQ) is known to function as an electron transport in mitochondria and an lipophilic antioxidant. Fission yeast S. pombe produces CoQ10 and its CoQ deficient mutants show various phenotypes. Fission yeast S. japonicus produces low levels of CoQ10, but phenotypes are not elucidated. In this study, S. japonicus wild type and CoQ deficient mutant showed respiratory deficiency and the severe sensitivity of oxidative stresses, but did not show production of sulfide and the growth delay in minimal medium.
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