Microbial-mediated production of lipids capable control of skin microbiome
| Project/Area Number |
18K05426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38020:Applied microbiology-related
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| Research Institution | Osaka Research Institute of Industrial Science and Technology |
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Principal Investigator |
Nagao Toshihiro 地方独立行政法人大阪産業技術研究所, 森之宮センター, 研究部長 (30416309)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 皮膚細菌叢 / Staphylococcus aureus / S. epidermidis / 抗菌活性 / パルミトレイン酸 / リン脂質 / 皮膚菌叢 |
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| Outline of Final Research Achievements |
Palmitoleic acid (POA) shows selective antibacterial activity which suppress the growth of harmful microorganism Staphylococcus aureus and does not suppress the growth of beneficial microorganism Staphylococcus epidermidis. In this study, we produced POA-containing phospholipids through phospholipase reaction with lyso-phospholipids because only S. aureus possesses enzymes hydrolyzing non-active POA-containing phospholipids to active POA. However the synthesized POA-containing phospholipids did not shows meaningful selective antibacterial activity.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、大腸、皮膚、口腔の常在微生物と健康・疾病の関係の研究が進展し、有用微生物を用いた臨床試験研究も進展し、腸内細菌に関する商品が出始めている。皮膚細菌叢については、アメリカにおいて、黄色ブドウ球菌だけの生育を抑制する微生物を用いたアトピー患者に対する臨床試験研究で効果が得られており、黄色ブドウ球菌の生育を抑制し、表皮ブドウ球菌の生育を抑制しないという選択的抗菌活性は有用であることが分かった。POAが持つ選択的抗菌活性の場合、エステル型ではなく、遊離型にしなければ効果を発揮できない事が本研究で判明し、今後、遊離型のPOAの活用が期待できる。
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Report
(6 results)
Research Products
(30 results)
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[Journal Article] Antimicrobial Activities of LL37 Fragment Mutant-Poly (Lactic-Co-Glycolic) Acid Conjugate Against Staphylococcus aureus, Escherichia coli, and Candida albicans2021
Author(s)
Takeshi Mori, Miyako Yoshida, Mai Hazekawa, Daisuke Ishibashi, Yoshiro Hatanaka, Toshihiro Nagao, Rie Kakehashi, Honami Kojima, Rio Uno, Minoru Ozeki, Ikuo Kawasaki, Taku Yamashita, Junichi Nishikawa, and Takahiro Uchida
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Journal Title
Int. J. Mol. Sci.
Volume: 22
Issue: 10
Pages: 5097-5107
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Targeted Delivery of Miconazole Employing LL37 Fragment Mutant Peptide CKR12-Poly (Lactic-Co-Glycolic) Acid Polymeric Micelles2021
Author(s)
Takeshi Mori, Miyako Yoshida, Mai Hazekawa, Daisuke Ishibashi, Yoshiro Hatanaka, Rie Kakehashi, Makoto Nakagawa, Toshihiro Nagao, Miki Yoshii, Honami Kojima, Rio Uno, and Takahiro Uchida
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Journal Title
Int. J. Mol. Sci.
Volume: 22
Issue: 21
Pages: 12056-12069
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effect of Dietary Partial Hydrolysate of Phospholipids, Rich in Docosahexaenoic Acid-Bound Lysophospholipids, on Lipid and Fatty Acid Composition in Rat Serum and Liver.2019
Author(s)
Ryota Hosomi , Kenji Fukunaga, Toshihiro Nagao, Toshifumi Tanizaki, Kazumasa Miyauchi, Munehiro Yoshida, Seiji Kanda, Toshimasa Nishiyama, and Koretaro Takahashi
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Journal Title
Journal of Food Science
Volume: 84
Issue: 1
Pages: 183-191
DOI
Related Report
Peer Reviewed
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