| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Proton-translocating inorganic pyrophosphatase is a membrane protein that hydrolyzes inorganic pyrophosphate and transport proton across the vacuolar membrane. An enzymatic reaction cycle has been built to explain the mechanism in which hydrolysis of one pyrophosphate is linked to the active transport of one proton. In this study, to verify this model and to make a more solid model, we solved the crystal structure of the state in which three-dimensional structures were not determined previously.
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