| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
While most natural peptides consist of L-amino acids, D-amino acids are also widely identified both in primary and secondary metabolites. The presence of D-amino acids in secondary metabolites is generally a hallmark of peptides biosynthesized via non-ribosomal peptide synthetases and only a few peptide epimerases that introduce D-amino acids residue into polypeptides via epimerization have been reported. In this study, we investigated two novel types of peptide epimerases and revealed novel enzyme chemistry.
|
