| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Because nutritional status in infancy influences the risk of metabolic diseases in adulthood, understanding the digestive and absorptive processes of nutrients in infants is important for the maintenance of lifelong health. In this study, we evaluated and analyzed the role of endocytosis and intracellular digestion in intestinal epithelial cells in order to understand the molecular mechanisms by which proteins in milk exert their physiological functions in the infant gastrointestinal tract. We analyzed the degradation of milk functional protein lactoferrin (LF) in the intestine of infant mice. The degradation was limited, and LF was absorbed into the body cavity even in its undegraded state. As a basic study for the functional analysis of milk components, we analyzed the changes in gene expression and intestinal microbiota during the development of the infant intestinal tract.
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