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Effect of acetic acid on the activation of G-protein-coupled receptor GPR43 in skeletal muscle cells and on the skeletal muscle function

Research Project

Project/Area Number 18K05476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionOkayama Prefectural University

Principal Investigator

Yamashita Hiromi  岡山県立大学, 保健福祉学部, 教授 (70254563)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsGPR43 / 酢酸 / 骨格筋 / 遅筋線維 / L6筋管細胞 / 骨格筋細胞 / ラット / AMPK / GPR / 短鎖脂肪酸 / 脂肪代謝
Outline of Final Research Achievements

GPR43 functioning involves the suppression of lipid accumulation and maintaining body energy homeostasis, and is activated by acetic acid or propionic acid. It was hypothesized that acetic acid would stimulate GPR43 in skeletal muscle cells and has function in modulating skeletal muscle function. The objective of the current study was to clarify the expression of GPR43 and the effect of acetic acid on the activation of GPR43 in the skeletal muscle cells. The GPR43 expression, observed in the differentiated myotube cells, was increased upon acetic acid treatment. Acetic acid induced the intracellular calcium influx and modulated genes expression associated with slow-twitch fibers in the cells and these effects were significantly inhibited by the GPR43-specific siRNA treatment. It was concluded that acetic acid plays a role in the activation of GPR43 and involves the proliferation of slow-twitch fibers in L6 skeletal muscles through the calcium-signaling pathway.

Academic Significance and Societal Importance of the Research Achievements

ラット骨格筋にGPR43が発現すること、さらに酢酸により活性化されることを明らかにした。酢酸による骨格筋GPR43の活性化の機序が明らかになったことから、GPR43の活性化を介して骨格筋機能を改善することができる。高齢化社会の我が国における課題となっている加齢による骨格筋の代謝異常を改善させ、健康寿命延長にも寄与できると考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (19 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] Age-related changes in energy metabolism and skeletal muscle function of Sprague-Dawley rats2021

    • Author(s)
      Yun Ma, Hitomi Maruta, Baojun Sun, Hiromi Yamashita
    • Journal Title

      岡山県立大学保健福祉学部紀要

      Volume: 27 Pages: 83-92

    • DOI

      10.15009/00002367

    • NAID

      120006978838

    • URL

      https://oka-pu.repo.nii.ac.jp/records/2402

    • Year and Date
      2021-03-12
    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Effects of long-term taurine supplementation on aging-related changes in Sprague-Dawley rats2021

    • Author(s)
      Yun Ma, Hitomi Maruta, Baojun Sun, Chengduo Wang, Chiaki Isono, Hiromi Yamashita
    • Journal Title

      Amino acid

      Volume: 53 Issue: 2 Pages: 159-170

    • DOI

      10.1007/s00726-020-02934-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetic acid stimulates G-protein-coupled receptor GPR43 and induces intracellular calcium influx in L6 myotube cells2020

    • Author(s)
      Hitomi Maruta and Hiromi Yamashita
    • Journal Title

      PloS One

      Volume: 15(9):e0239428 Issue: 9 Pages: 1-19

    • DOI

      10.1371/journal.pone.0239428

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal variations in major components of Crassostrea gigas from Seto Inland Sea2020

    • Author(s)
      Chiaki Isono, Hitomi Maruta, Yun Ma, Natsuki Ganeko, Tsuyoshi Miyake, Hiromi Yamashita
    • Journal Title

      Fishery Science

      Volume: 86 Issue: 6 Pages: 1087-1099

    • DOI

      10.1007/s12562-020-01458-6

    • NAID

      40022414280

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 研究室で学んでみませんか2019

    • Author(s)
      山下広美
    • Journal Title

      臨床栄養

      Volume: 135 Pages: 824-825

    • Related Report
      2019 Research-status Report
  • [Journal Article] 酢酸の生理機能性を軸にしたこれまでの研究と栄養学分野での教育活動2018

    • Author(s)
      山下広美
    • Journal Title

      日本栄養学教育学会雑誌

      Volume: 3 Pages: 19-24

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 酢酸の生理機能性と利用2021

    • Author(s)
      山下広美
    • Organizer
      令和2年度食品技術ミニシンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 新規ビフィズス菌株の特性と肥満抑制効果に関する研究2020

    • Author(s)
      丸田ひとみ、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The effects of long-term taurine supplementation on SD ageing rats2020

    • Author(s)
      Yun Ma, Baojun Sun, Hitomi Maruta, Chengduo Wang , Hiromi Yamashita
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 瀬戸内海沿岸で養殖されたマガキ含有成分の季節および地域差の解析2020

    • Author(s)
      山下 広美、礒野 千晶、板谷 智恵美、孫 宝軍、丸田 ひとみ
    • Organizer
      第72回日本家政学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肥満抑制効果を持つ新規ビフィズス菌株に関する研究2020

    • Author(s)
      丸田ひとみ、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      第53回日本栄養・食糧学会中国・四国支部大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新規ビフィズス菌株の肥満抑制効果2020

    • Author(s)
      丸田ひとみ、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ビフィズス菌発酵乳の抗肥満効果2019

    • Author(s)
      丸田ひとみ、王承鐸、天満晴菜、馬芸、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規ビフィズス菌発酵乳の肥満抑制効果2019

    • Author(s)
      丸田ひとみ、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      第52回日本栄養・食糧学会中国・四国支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 酢酸の骨格筋における生理機能2019

    • Author(s)
      丸田ひとみ、山下広美
    • Organizer
      岡山実験動物研究会第77回例会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effect of Bifidobacterium fermented milk on anti-obesity2019

    • Author(s)
      Hitomi Maruta, Syoji Nakamura, Yusuke Fujii, Naoki Toyokawa and Hiromi Yamashita
    • Organizer
      ICPH2019KOBE The 9th International Conference on Polyphenols and Health
    • Related Report
      2019 Research-status Report
  • [Presentation] Study on mechanism of taurine function on skeletal muscle and liver of SD aged rat2019

    • Author(s)
      Yun Ma, Hitomi Maruta, Chengduo Wang, Hiromi Yamashit
    • Organizer
      国際タウリン研究会日本部会
    • Related Report
      2018 Research-status Report
  • [Presentation] 瀬戸内海沿岸で養殖されたマガキ含有成分の解析および機能性の検討2019

    • Author(s)
      礒野千晶、丸田ひとみ、三宅剛史、山下広美
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ビフィズス菌発酵乳の肥満抑制効果に関する研究2018

    • Author(s)
      丸田ひとみ、Wang Chengduo、天満晴菜、Ma Yun、中村昇二、藤井祐介、豊川直樹、山下広美
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 酢酸塩による肥満抑制効果の検討2018

    • Author(s)
      丸田ひとみ、富田真江、田中沙都、山下広美
    • Organizer
      第51回日本栄養・食糧学会中国・四国支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effect of Bifidobacterium fermented milk on anti-obesity2018

    • Author(s)
      Hitomi Maruta1*, Chengduo Wang2, Haruna Tenma1, Yun Ma2, Syoji Nakamura, Yusuke Fujii, Naoki Toyokawa and Hiromi Yamashita
    • Organizer
      3rd International Conference on Biologically Active Substances Bioactive Okayama 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Beneficial effect of functional foods on fatty liver2018

    • Author(s)
      Chengduo Wang, Hitomi Maruta, Yun Ma, Syoji Nakamura, Yusuke Fujii, Naoki Toyokawa, Hiromi Yamashita
    • Organizer
      3rd International Conference on Biologically Active Substances Bioactive Okayama 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 2.Study on mechanism of taurine function on skeletal muscle of aged rats2018

    • Author(s)
      Yun Ma, Hitomi Maruta, Chengduo Wang, Hiromi Yamashita
    • Organizer
      3rd International Conference on Biologically Active Substances Bioactive Okayama 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 4.Effect of acetic acid intake on muscle quality and expressions of atrophy-related genes of aged rats2018

    • Author(s)
      Hitomi Maruta, Reina Abe, Ma Yun, Aya Araki, Chiaki Isono, Hiromi Yamashita
    • Organizer
      11th International SCWD Conference on Cachexia, Sarcopenia and Muscle Wasting
    • Related Report
      2018 Research-status Report
  • [Presentation] 瀬戸内海の養殖マガキの栄養と特徴2018

    • Author(s)
      山下広美
    • Organizer
      第72回日本栄養・食糧学会大会、ランチョンセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 食べ物と健康 食品の科学2018

    • Author(s)
      山下広美 他
    • Total Pages
      331
    • Publisher
      南江堂
    • Related Report
      2018 Research-status Report
  • [Book] 分子栄養学2018

    • Author(s)
      山下広美 他
    • Total Pages
      223
    • Publisher
      講談社
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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