| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have previously reported that gut microbiota dysbiosis was associated with the outcome of acute ischemic stroke in diabetic mice. Recent studies have shown that the gut microbiota plays an important role in controlling the differentiation of immune cells in the intestinal tract.
In this study, we found that diabetic mice fed a high-fat diet had increased Th17 cells within lamina propria of the small intestine, and had severe neurological dysfunction after ischemic stroke compared to control mice fed a low-fat diet. These findings suggest that intestinal T lymphocytes are associated with the outcome of acute ischemic stroke.
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