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Elucidation of colon homeostasis focusing on the crosstalk between gut microbiota and IL-5-producing cells

Research Project

Project/Area Number 18K05499
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionToyama Prefectural Institute for Pharmaceutical Research

Principal Investigator

Yanagibashi Tsutomu  富山県薬事総合研究開発センター, その他部局等, 主任研究員 (60710887)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsIgA / IL-5 / 腸内細菌
Outline of Final Research Achievements

There are more than 1000 species of symbiotic microbiota in the human intestine. Recent studies have shown that gut dysbiosis is associated with the pathogenesis of several diseases. Host immunity is thought to regulate the composition of microorganisms, but the details are largely unknown. This study focused on the relationship between interleukin-5 (IL-5), which is constantly produced by group 2 innate lymphoid cells in the large intestine, and the symbiotic microbial flora. In this study, we demonstrated that a part of the T cell-independent immunoglobulin A, one of the regulators of symbiotic homeostasis, is produced in an IL-5-dependent manner. In addition, intestinal dysbiosis was observed in T cell and IL-5 double knockout mice. These results indicate that IL-5 contributes appropriate composition of the gut microbiota via T cell-independent IgA production.

Academic Significance and Societal Importance of the Research Achievements

本研究では,大腸で恒常的に産生されているインターロイキン(IL)-5が,免疫グロブリンA産生を介して腸内細菌の構成バランスの維持に寄与することを示し,宿主免疫系による腸内細菌制御機構の一端を明らかにした。近年,腸内細菌の構成バランスの破綻が,炎症腸疾患,代謝疾患および神経疾患等の原因となることが明らかにされつつあり,これら疾病の治療や予防に腸内細菌を適正な状態に維持する取り組みがなされている。本研究の成果から,腸管IL-5産生量を適正に調節することで,腸内細菌構成バランスの破綻に起因する疾病の予防や治療へ応用が可能であると考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 Other

All Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Presentation] Vitamin A-dependent IL-33 production maintains IL-5-producing ILC2s in the large intestine2019

    • Author(s)
      Tsutomu Yanagibashi, Masashi Ikutani, Yoshinori Nagai, Kiyoshi Takatsu
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] The role of IL-5-producing group 2 innate lymphoid cells in the large intestin2018

    • Author(s)
      Tsutomu Yanagibashi, Masashi Ikutani, Yoshinori Nagai, Yukihiko Aikawa, Kiyoshi Takatsu
    • Organizer
      The 5th Toyama-Basel Joint Symposium on Pharmaceutical Research and Drug Development
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 富山県薬事総合研究開発センター

    • URL

      https://www.pref.toyama.jp/1285/kurashi/kenkou/iryou/1285/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 富山県薬事総合研究開発センター

    • URL

      http://www.pref.toyama.jp/branches/1285/

    • Related Report
      2019 Research-status Report 2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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