| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We created a model in which the mother rat was hyperglycemia by feeding a high-fat diet (HF) from the pregnancy to the lactation period, and the newborn rat also maintained the hyperglycemia from the weaning to the post-growth period. In an oral glucose tolerance test at 8 weeks of age, hyperglycemia in the HF group persisted until 3 hours later but showed a tendency to improve in the rat which was administered bovine lactoferrin (bLf) during the lactation period. In addition, the pancreas islet size was significantly increased by the bLf administration, as a result of increase in the number of beta-cell. Since pancreatic GIP and GLP-1 receptors expression was promoted by bLf administration, it was suggested that bLf could maintain insulin release from the pancreas and improve glucose metabolism via incretin response.
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