| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
NAFLD is one of multiple factorial diseases caused by the interaction between genetic factor and environmental factor. Genetic analysis of high-fat induced fatty liver model SMXA-5 mice, derived from fatty liver-resistant parental strains, revealed that Iah1 was a candidate gene for fatty liver. I constructed two Iah1 knockout mice (A/J-12SM Iah1 KO and B6N-Iah1 KO). These Iah1 knockout mice did not show the accumulation of triglycerides in liver. This study showed that Iah1 gene was not involved in the development of high-fat induced-fatty liver.
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