| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Japanese cedar and cypress pollen allergens occur Lewis a antigen-containing N-glycans. Although the core structure of plant antigenic N-glycans, M3FX, suppress Th2 immune response, the immune activity of Lewis a antigen-containing N-glycans has not been elucidated. In this study, we purified a large amount of Lewis a antigen-containing N-glycans from glycoproteins expressed in Egeria densa and synthesized a multivalent glycopolymer. It was suggested that the glycopolymers suppressed antigen presentation by dendritic cell-like cell lines and may contribute to the suppression of Th2 immune responses.
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