Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Outline of Final Research Achievements |
The insect cuticle is a non-cellular matrix composed of chitin fibers and chitin-binding cuticle proteins. It is postulated that cuticular components are cross-linked together through chemical reactions catalyzed by multicopper oxidase-2 (MCO2). This study focused on identification and function analyses of protein factors that are involved in cuticle hardening as substrates of this enzyme. From sequence information obtained from large insect species, a group of proteins with their own characteristic in their sequences were found. The proteins of this group had not been analyzed before, but information in database suggests that the protein group has very important roles in cuticle formation. In relation with these proteins, it was proposed that chemical reactions catalyzed by oxidases other than MCO2 might be involved in cuticle formation.
|