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Development of micro-structured surfaces with anti-fouling activities based on the biofilm formation mechanism of marine benthic diatoms

Research Project

Project/Area Number 18K05812
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 40040:Aquatic life science-related
Research InstitutionAsahikawa Medical College

Principal Investigator

Murosaki Takayuki  旭川医科大学, 医学部, 准教授 (40551693)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高分子材料 / 微細形状 / 生物付着 / 付着生物 / バイオフィルム / 防汚技術 / 防汚材料 / 表面微細構造 / 付着珪藻 / 防汚
Outline of Final Research Achievements

In this study, we investigated the biofilm formation on the substrates with several surface properties.
From the results, the experimental system for settlement assay using benthic diatom (Navicula sp.) was established. This allowed us to observe the biofilm development on the substrates with different surface characteristics. It was found that the growth rates of bentihc diatoms was different on each surface with different surface functional groups, and especially that the diatom growth rate on the surface with OH groups was lower compared to other substrates. Furthermore, the results of settlement assay on the surfaces with different microstructures showed a negative correlation between initial cell distribution and surface coverage. This result suggested that the surface microstructure might restrict cell motility.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から,Navicula種が付着実験に用いるモデル生物に適している事が明らかとなった。付着実験系の構築に成功した事で,今後は安定した室内環境での生物皮膜形成過程の調査が可能となった。既存の研究では,付着基質表面での付着生物の付着や剥離といった結果のみが着目され,途中の過程は報告が少ない。また,防汚の面では化学物質の徐放による生物防除が主流である。表面の物理化学的な性質による生物皮膜形成過程に焦点を当てた事が,本研究の特色である。その結果,初期の細胞分散性が増殖速度に影響を与える可能性を明らかにした。本研究から得られた知見は,防汚技術・水産増殖技術両方において有用なものと考えられる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (59 results)

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (48 results) (of which Int'l Joint Research: 14 results,  Invited: 12 results) Book (4 results)

  • [Journal Article] 性状の異なる表面における付着生物の付着基質選択性2024

    • Author(s)
      室﨑喬之
    • Journal Title

      粉体工学会誌

      Volume: 61(4) Pages: 213-219

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 付着生物の付着基質選択性を利用した低環境負荷型の新規防汚材料開発について2024

    • Author(s)
      室﨑喬之
    • Journal Title

      MATERIAL STAGE

      Volume: 24(2) Pages: 1-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antifouling Activity of Hydroxyl Functional Groups in PVA Thin Films Against the Settlement of Sessile Organisms in Laboratory and Field Conditions2020

    • Author(s)
      Takayuki Murosaki, Ai Momose, Yasuyuki Nogata, Shinya Onodera, Otohiko Azuma, Yuji Hirai
    • Journal Title

      Journal of Photopolymer Science and Technology

      Volume: 33 Issue: 6 Pages: 591-598

    • DOI

      10.2494/photopolymer.33.591

    • NAID

      130007966673

    • ISSN
      0914-9244, 1349-6336
    • Year and Date
      2020-12-15
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Verifications of the antifouling effect of the cross-linked PVA coating2020

    • Author(s)
      百々瀬愛, 室崎喬之, 野方靖行, 小野寺真也, 東乙比古, 下村政嗣, 平井悠司
    • Journal Title

      Sessile Organisms

      Volume: 37 Issue: 1 Pages: 1-9

    • DOI

      10.4282/sosj.37.1

    • NAID

      130007853741

    • ISSN
      1342-4181, 1883-4701
    • Year and Date
      2020-05-16
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 付着基質表面の性状による付着生物の接着制御2020

    • Author(s)
      室﨑喬之
    • Journal Title

      医学のあゆみ

      Volume: 275(7) Pages: 842-848

    • Related Report
      2020 Research-status Report
  • [Journal Article] Barnacle Settlement Behaviors on Microstructured Surfaces with Different Geometric Parameters2019

    • Author(s)
      Murosaki Takayuki, Abe Kentaro, Nogata Yasuyuki, Hirai Yuji
    • Journal Title

      Journal of Photopolymer Science and Technology

      Volume: 32 Issue: 2 Pages: 303-308

    • DOI

      10.2494/photopolymer.32.303

    • NAID

      130007744367

    • ISSN
      0914-9244, 1349-6336
    • Year and Date
      2019-06-24
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 付着基質表面の微細形状がフジツボの付着に及ぼす影響2019

    • Author(s)
      室崎喬之, 平井悠司, 野方靖行
    • Journal Title

      塗装工学

      Volume: 54(2) Pages: 446-451

    • Related Report
      2019 Research-status Report
  • [Presentation] The settlement behaviors of sessile organisms on the surfaces with patterned functional groups2023

    • Author(s)
      Takayuki Murosaki, Jumpei Watanabe, Yuji Hirai, Yasuyuki Nogata
    • Organizer
      The 40th International Conference of Photopolymer Science and Technology(ICPST-40)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 異なるSAM基板上におけるフジツボ幼生の探索挙動解析2023

    • Author(s)
      浅野祥大, 室﨑喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      2023年度北海道高分子若手研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Analysis of barnacle larval exploration behaviors on substrates modified with different surface functional groups2023

    • Author(s)
      Shota Asano, Takayuki Murosaki, Yasuyuki Nogata, Masatsugu Shimomura, Yuji Hirai
    • Organizer
      KJF International Conference on Organic Materials for Electronics and Photonics 2023 (KJF-ICOMEP 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 異なる表面官能基を修飾させた基板上でのフジツボ幼生の接着挙動解析2023

    • Author(s)
      浅野祥大, 室﨑喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      第72回高分子討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] SAM基板上におけるフジツボ探索挙動の動画解析2023

    • Author(s)
      浅野祥大, 渡邉純平, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      2023年度日本付着生物学会研究集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 表面官能基パターニング基板上におけるフジツボキプリス幼生の付着評価2022

    • Author(s)
      渡邊純平, 三上恵, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      第71回高分子学会年次大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Growth behaviors of marine benthic diatoms on the surfaces with micro dimple arrays2022

    • Author(s)
      Takayuki Murosaki, Taiki Kishigami, Yuji Hirai, Yasuyuki Nogata
    • Organizer
      The 39th International Conference of Photopolymer Science and Technology(ICPST-39)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 海洋生物の付着基質選択性と付着制御技術2022

    • Author(s)
      室﨑 喬之, 渡邊 純平, 平井 悠司, 野方 靖行
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 異なる表面官能基でマイクロパターン化されたSAM基板上で のフジツボ付着評価2022

    • Author(s)
      渡邊純平, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      第71回高分子討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 付着生物の付着基質選択性 -表面官能基の種類,面積率,及び幾何的パターンに関して-2022

    • Author(s)
      室﨑 喬之, 渡邊 純平, 岸上 大輝, 平井 悠司, 野方 靖行
    • Organizer
      第73回コロイドおよび界面化学討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 表面微細構造上における付着珪藻の増殖挙動2022

    • Author(s)
      室﨑 喬之, 渡邊 純平, 平井 悠司, 野方 靖行
    • Organizer
      第60回日本生物物理学会年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Investigation of the larval surface recognition abilities of barnacles on the surfaces with several patterned surface functional groups2022

    • Author(s)
      Jumpei Watanabe, Takayuki Murosaki, Yasuyuki Nogata, Masatsugu Shimomura, Yuji Hirai
    • Organizer
      Chitose International Forum on Science & Technology 2022 (CIF 22)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 表面官能基の幾何学的なパターンがフジツボキプリス幼生の着生に与える影響2022

    • Author(s)
      渡邊純平, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      日本付着生物学会 50 周年記念シンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] Barnacle Settlements on the Dot-patterned SAM surfaces2022

    • Author(s)
      Jumpei Watanabe, Takayuki Murosaki, Yasuyuki Nogata, Masatsugu Shimomura, Yuji Hirai
    • Organizer
      35th International Microprocesses and Nanotechnology Conference (MNC2022)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 海洋付着生物の付着基質選択性に着目した付着制御技術2022

    • Author(s)
      室崎喬之
    • Organizer
      NBCI テクノロジー委員会 バイオミメティクス分科会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 表面性状による付着生物の接着制御 ~「付」と「着」~2022

    • Author(s)
      室崎喬之
    • Organizer
      PWCバイオミメティクス研究クラスター講演会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 付着基質表面のマイクロディンプル形状が付着珪藻(Navicula sp.)の付着挙動に及ぼす影響2022

    • Author(s)
      岸上大輝, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      2022年度日本付着生物学会研究集会
    • Related Report
      2021 Research-status Report
  • [Presentation] The pre-settlement behaviors of barnacles on antifouling micro-topographic surfaces2021

    • Author(s)
      Takayuki Murosaki, Yasuyuki Nogata, Yuji Hirai
    • Organizer
      The 38th International Conference of Photopolymer Science and Technology(ICPST-38)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 付着基質の表面形状を利用した海洋生物付着抑制技術2021

    • Author(s)
      室崎喬之
    • Organizer
      表面技術協会北海道支部及び腐食防食学会北海道支部 2021年北海道夏期セミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] フジツボキプリス幼生の着生前探索行動と付着基質表面性状との関係2021

    • Author(s)
      室崎喬之
    • Organizer
      ベントス・プランクトン合同大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] The adhesion of marine benthic diatoms on the surfaces with hexagonal packed micro dimple arrays2021

    • Author(s)
      Taiki Kishigami, Takayuki Murosaki, Yasuyuki Nogata, Masatsugu Shimomura, Yuji Hirai
    • Organizer
      34th International Microprocesses and Nanotechnology Conference (MNC2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigation of the influence of a surface functional group against barnacle settlements using the 3D printed new experimental setup2021

    • Author(s)
      Kei Mikami, Jumpei Watanabe, Takayuki Murosaki, Yasuyuki Nogata, Masatsugu Shimomura, Yuji Hirai
    • Organizer
      The 9th International Symposium on Surface Science(ISSS-9)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Selectivity for surface functional groups during larvae of barnacles2021

    • Author(s)
      Jumpei Watanabe, Kei Mikami, Takayuki Murosaki, Yasuyuki Nogata, Masatsugu Shimomura, Yuji Hirai
    • Organizer
      The 9th International Symposium on Surface Science(ISSS-9)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 表面微細構造と表面化学組成を組み合わせた基板上におけるフジツボ付着の調査2020

    • Author(s)
      三上恵, 百々瀬愛, 室崎喬之, 野方靖行, 平井悠司, 下村政嗣
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] フィールド環境下における海洋付着生物に対する PVA 薄膜の抗付着効果2020

    • Author(s)
      室崎 喬之, 百々瀬 愛, 野方 靖行, 小 野寺 真也, 東 乙比古, 平井 悠司
    • Organizer
      第71回コロイドおよび界面化学討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effects of surface functional groups against barnacle settlement2020

    • Author(s)
      Kei Mikami, Ai Momose, Takayuki Murosaki, Yasuyuki Nogata, Yuji Hirai, Masatsugu Shimomura
    • Organizer
      MNC 2020, 33rd International Microprocesses and Nanotechnology Conference
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 着生防止基板を同時評価可能な新規フジツボ着生実験系の検討2020

    • Author(s)
      三上恵, 渡邊純平, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      2021年度日本付着生物学会研究集会
    • Related Report
      2020 Research-status Report
  • [Presentation] フジツボキプリス幼生着生時の表面官能基に対する選択性2020

    • Author(s)
      渡邊純平, 三上恵, 室崎喬之, 野方靖行, 下村政嗣, 平井悠司
    • Organizer
      2021年度日本付着生物学会研究集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 材料の表面形態と海洋付着生物(主にフジツボ類)の付着に関する最新のトピックス2020

    • Author(s)
      室崎喬之
    • Organizer
      旭川高専特別講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ヒドロキシ基比率の異なる基板上におけるフジツボの付着挙動2020

    • Author(s)
      三上恵, 百々瀬愛, 室崎喬之, 平井悠司, 野方靖行, 下村政嗣
    • Organizer
      2020年度日本付着生物学会研究集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒドロキシ基比率の異なる基板上におけるフジツボ付着の調査2019

    • Author(s)
      百々瀬愛, 瀬川雄太, 室崎喬之, 平井悠司, 野方靖行, 下村政嗣
    • Organizer
      第68回高分子年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Barnacle settlement behaviors on microstructured surfaces with different geometric parameters2019

    • Author(s)
      Takayuki Murosaki, Yasuyuki Nogata, Yuji Hirai
    • Organizer
      The 36th International Conference of Photopolymer Science and Technology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 表面微細構造による海洋付着生物の付着抑制技術2019

    • Author(s)
      室崎喬之
    • Organizer
      2019 年度 粉体操作に伴う諸現象に関する勉強会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 末端 OH / COOH基混合自己組織化単分子膜上でのフジツボの付着挙動2019

    • Author(s)
      百々瀬愛, 室崎喬之, 平井悠司, 野方靖行, 下村政嗣
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Pre-settlement behaviors of cypris larvae of the barnacle, Amphibalanus amphitrite, on the micro-structured surfaces2019

    • Author(s)
      Takayuki Murosaki, Yasuyuki Nogata, Yuji Hirai
    • Organizer
      The open International Symposium: Reproductive Biology of Barnacles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Settlement behavior of sessile organisms on micro-structured surfaces2019

    • Author(s)
      Takayuki Murosaki, Yasuyuki Nogata, Yuji Hirai
    • Organizer
      Okinawa Colloids 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Antifouling coatings of cross-linked PVA against marine sessile organisms2019

    • Author(s)
      Ai Momose, Takayuki Murosaki, Yuji Hirai, Yasuyuki Nogata, Masatsugu Shimomura
    • Organizer
      Okinawa Colloids 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 環境下におけるヒドロキシ基修飾表面及び PVAフィルムの付着生物に対する防汚性2019

    • Author(s)
      室崎喬之, 百々瀬愛, 小野寺真也, 東乙比古, 平井悠司
    • Organizer
      2019年度日本付着生物学会研究集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 自己組織化単分子膜表面のヒドロキシ基比率とフジツボの着生との関係2019

    • Author(s)
      百々瀬愛, 瀬川雄太, 平井悠司, 下村政嗣, 室﨑喬之, 野方靖行
    • Organizer
      2019年度日本付着生物学会研究集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 表面化学組成の違いがフジツボの付着に及ぼす影響2018

    • Author(s)
      百々瀬愛, 瀬川雄太, 室崎喬之, 平井悠司, 野方靖行, 下村政嗣
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluations of barnacle settlements on self-assembled monolayer surfaces2018

    • Author(s)
      Ai Momose, Yuta Segawa, Takayuki Murosaki, Yuji Hirai, Yasuyuki Nogata, Masatsugu Shimomura
    • Organizer
      14th International Conference on Modern Materials and Technologies(CIMTEC2018)
    • Related Report
      2018 Research-status Report
  • [Presentation] 有機多孔質材料の表面形状によるフジツボの付着制御2018

    • Author(s)
      室崎喬之
    • Organizer
      142委員会ABC合同研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 付着生物フジツボとその汚損対策2018

    • Author(s)
      室崎喬之
    • Organizer
      海生生物付着防止・防汚勉強会
    • Related Report
      2018 Research-status Report
  • [Presentation] フジツボの付着場所選択行動を利用した防汚材料開発2018

    • Author(s)
      室崎喬之, 野方靖行, 平井悠司
    • Organizer
      バイオミメティクス研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 海洋付着生物に対する表面微細構造を用いた低環境負荷型防汚材料の開発2018

    • Author(s)
      室崎喬之, 野方靖行, 平井悠司
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 基板表面のヒドロキシ基がフジツボの付着に与える影響2018

    • Author(s)
      百々瀬愛, 瀬川雄太, 室崎喬之, 平井悠司, 野方靖行, 下村政嗣
    • Organizer
      第67回高分子討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 海洋付着生物フジツボと低環境負荷型防汚材料2018

    • Author(s)
      室崎喬之, 野方靖行, 平井悠司
    • Organizer
      バイオ・高分子研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Investigation of the barnacle settlements on the surfaces with different hydroxyl group ratio2018

    • Author(s)
      Ai Momose, Yuta Segawa, Takayuki Murosaki, Yuji Hirai, Yasuyuki Nogata, Masatsugu Shimomura
    • Organizer
      The 12th SPSJ International Polymer Conference (IPC2018)
    • Related Report
      2018 Research-status Report
  • [Book] “Anti-Biofouling Effects against Sessile Organisms of Soft Materials” in Biomimetics -Connecting Ecology and Engineering by Informatics- (Edited By Akihiro Miyauchi, Masatsugu Shimomura)2022

    • Author(s)
      Takayuki Murosaki
    • Total Pages
      340
    • Publisher
      Jenny Stanford Publishing
    • ISBN
      9789814968102
    • Related Report
      2022 Research-status Report
  • [Book] "Section II. Approaches to Antifouling, Chapter 7. Barnacle Settlement on Soft Materials", Barnacles: Recent Progress in Biology and Antifouling2018

    • Author(s)
      Takayuki Murosaki (edited by R. Kado, H. Mimura and N. Endo)
    • Total Pages
      151
    • Publisher
      Nova Science Publishers
    • ISBN
      9781536134445
    • Related Report
      2018 Research-status Report
  • [Book] 「6.1.5 非線形ダイナミクス」, 第4版 現代界面コロイド化学の基礎-原理・応用・測定ソリューション2018

    • Author(s)
      眞山博幸, 室﨑 喬之, 秋田谷龍男
    • Total Pages
      544
    • Publisher
      公益社団法人日本化学会
    • ISBN
      9784621302910
    • Related Report
      2018 Research-status Report
  • [Book] 「第12章6節 付着生物フジツボに対するハイドロゲルの抗付着効果」, 動物学の百科事典2018

    • Author(s)
      室崎喬之(公益社団法人日本動物学会 編)
    • Total Pages
      800
    • Publisher
      丸善出版
    • ISBN
      9784621303092
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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