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Mechanism of action of oxidative environmental stress on fish health and its control based on scientific evidence

Research Project

Project/Area Number 18K05814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 40040:Aquatic life science-related
Research InstitutionTohoku University

Principal Investigator

Nakano Toshiki  東北大学, 農学研究科, 助教 (10217797)

Co-Investigator(Kenkyū-buntansha) 白川 仁  東北大学, 農学研究科, 教授 (40206280)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Discontinued (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords環境ストレス / 酸化ストレス / 魚類 / バイオマーカー / 水産化学 / 養殖魚 / ギンザケ / 感染 / Edwardsiella tarda / ストレスタンパク質 / HSP / SOD / 水産 / ストレス / 多環芳香族炭化水素 / 生理 / 農林水産物 / 環境化学 / 水族栄養学 / 水族養殖学
Outline of Final Research Achievements

Fish are often subjected to environmental stress. This stress can affect their growth. In this study, coho salmon were fasted or given the antibiotic oxytetracycline (OTC) to investigate the effects on biochemical parameters.
The expression level of HSP 70 in the liver was increased by fasting and OTC administration. Tissue glutathione levels were unchanged by fasting, whereas OTC treatment increased them in the liver. As for plasma components, fasting and OTC administration increased glucose level and slightly changed lipid components.
These findings suggest that fasting and OTC administration induces stress, however the effect of fasting on the individual is not so large. It was also suggested that antioxidative substances would be useful to reduce the stress in fish body due to environmental stress such as chemical stress.

Academic Significance and Societal Importance of the Research Achievements

近年、天然水産資源の減少により、世界的に養殖魚に対する需要が高まっている。既に水産物由来のタンパク質源の約半分は養殖生産に依存しており、間もなく天然物との比率は逆転すると言われている。従って、養殖魚のストレスを軽減し健康を維持することは、生産性の向上と生産量の維持を可能とし、世界的な食料供給に大きく貢献すると考えられる。本研究で得られたストレスに関する研究結果は、魚類のストレス反応に関する基礎的な学術知見の提供だけでなく、前述の問題を解決するためにも重要と思われる。すなわち、今後の人類の食料供給と福祉に貢献しうる成果ととらえられ、今後のさらなる展開が期待される。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (5 results) Book (1 results)

  • [Int'l Joint Research] ワーゲニンゲン大学(オランダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Fisheries and Oceans Canada(カナダ)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Effect of bacterial infection on the expression of stress proteins and antioxidative enzymes in Japanese flounder.2020

    • Author(s)
      Nakano, T., Osatomi, K., Miura, N., Aikawa-Fukuda, Y., Kanai, K., Yoshida, A., Shirakawa, H., Yamauchi, A., Yamaguchi, T., and Ochiai, Y.
    • Journal Title

      Evolution of Marine Coastal Ecosystems under the Pressure of Global Changes

      Volume: - Pages: 111-127

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress in fish and application of carotenoid for aquafeed as an anti-stress supplement2020

    • Author(s)
      Nakano, T.
    • Journal Title

      Encyclopedia of Marine Biotechnology

      Volume: - Pages: 2999-3019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Properties of carotenoids in fish fitness: A review2020

    • Author(s)
      Nakano, T. and Wiegertjes, G.
    • Journal Title

      Marine Drugs

      Volume: 18 Issue: 11 Pages: 568-568

    • DOI

      10.3390/md18110568

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of bacterial infection on the expression of stress proteins and antioxidative enzymes in Japanese flounder2020

    • Author(s)
      T. Nakano, K. Osatomi, N. Miura, Y. Aikawa-Fukuda, K. Kanai, A. Yoshida, H. Shirakawa, A. Yamauchi,T. Yamaguchi, Y. Ochiai
    • Journal Title

      Evolution of Marine Coastal Ecosystems under the Pressure of Global Changes

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative metabolome profiling of growth hormone transgenic coho salmon by capillary electrophoresis time-of-flight mass spectrometry.2019

    • Author(s)
      T. Nakano, H. Shirakawa, G. Yeo, R.H. Devlin, T. Soga
    • Journal Title

      The Sea Under Human and Natural Impacts

      Volume: - Pages: 223-234

    • DOI

      10.1007/978-3-030-00138-4_18

    • ISBN
      9783030001377, 9783030001384
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a Novel Enhanced Biosensor System for Real-Time Monitoring of Fish Stress Using a Self-Assembled Monolayer2019

    • Author(s)
      H. Wu, Y. Fujii, T. Nakano,T. Arimoto, M. Murata, H. Matsumoto,Y. Yoshiura, H. Ohnuki, and H. Endo
    • Journal Title

      Sensors

      Volume: 19 Issue: 7 Pages: 1518-1518

    • DOI

      10.3390/s19071518

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative metabolome profiling of growth hormone transgenic coho salmon by capillary electrophoresis time-of-flight mass spectrometry.2019

    • Author(s)
      T. Nakano*, H. Shirakawa, G. Yeo, R.H. Devlin, and T. Soga
    • Journal Title

      Oceanography Challenges to Future Earth

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] カロテノイドの種類と生物活性2018

    • Author(s)
      中野俊樹
    • Journal Title

      養殖ビジネス

      Volume: 55 Pages: 36-40

    • Related Report
      2018 Research-status Report
  • [Presentation] ギンザケの生化学的バイオマーカーに及ぼす化学物質の影響2020

    • Author(s)
      中野俊樹・白川 仁・山口敏康・落合芳博
    • Organizer
      令和2年度日本水産学会春季大会(東京海洋大学品川キャンパス)
    • Related Report
      2019 Research-status Report
  • [Presentation] ギンザケにおける多環芳香族炭化水素によるストレスの影響2019

    • Author(s)
      中野俊樹・山内晶子・山口利康・落合芳博
    • Organizer
      2019 年度日仏海洋学会学術研究発表会(日仏会館、東京)
    • Related Report
      2019 Research-status Report
  • [Presentation] ギンザケの抗酸化的バイオマーカーに及ぼすオキシテトラサイクリンの影響2019

    • Author(s)
      中野俊樹・白川 仁・山口敏康・落合芳博
    • Organizer
      令和元年度日本水産学会秋季大会(福井県立大学永平寺キャンパス)
    • Related Report
      2019 Research-status Report
  • [Presentation] オキシテトラサイクリンがギンザケの生化学的性状に及ぼす影響について2019

    • Author(s)
      中野俊樹、齋藤茉希、山口敏康、落合芳博
    • Organizer
      平成31年度日本水産学会春季大会(東京海洋大学品川キャンパス)
    • Related Report
      2018 Research-status Report
  • [Presentation] 多環芳香族炭化水素がギンザケのレドックス状態に及ぼす影響について2018

    • Author(s)
      中野俊樹、岡本円香、佐々木春佳、齋藤茉希、山内晶子、山口敏康、落合芳博
    • Organizer
      平成30年度日本水産学会秋季大会(広島大学東広島キャンパス)
    • Related Report
      2018 Research-status Report
  • [Book] 放射光利用の手引き2019

    • Author(s)
      中野俊樹
    • Total Pages
      332
    • Publisher
      アグネ技術センター
    • ISBN
      9784901496957
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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