| Project/Area Number |
18K05937
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42010:Animal production science-related
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Sugimura Satoshi 東京農工大学, (連合)農学研究科(研究院), 准教授 (00728454)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 卵母細胞 / 発生能 / 卵胞細胞 / ウシ / 卵子 / 成熟 / 卵丘細胞 / cAMP / PKA / 卵胞発育 / 体外成熟 / トランスクリプトーム |
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| Outline of Final Research Achievements |
The developmental competence, which is a function of oocytes, is regulated by follicular cells such as cumulus cells and granulosa cells that surround them. So far, I showed that follicle growth treatment (FGT) with FSH improves the developmental competence of oocytes. From RNA-seq and metabolome analysis, it was shown that FGT with FSH suppresses excessive glucose metabolism of follicle cells, thereby suppressing follicle cell regression and migration. Hence I demonstrated that the developmental competence of oocytes is acquired and maintained by the coupling of the follicular cell-oocyte signaling network.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究において、卵母細胞の機能的完全性、すなわち、発生能の獲得・維持機構の一旦が明らかになった。卵母細胞の発生能獲得機構の全容解明の一助になるだけでなく、本研究の知見に基づいた卵母細胞の体外培養系の開発により、家畜の効率的生産、育種改良の迅速化が期待される。
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