New aproach for canine lymphoma studies by a metabolic profile analysis
| Project/Area Number |
18K05972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
OKUDA MASARU 山口大学, 共同獣医学部, 教授 (10325243)
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| Co-Investigator(Kenkyū-buntansha) |
上林 聡之 山口大学, 共同獣医学部, 助教 (50796414)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | リンパ腫 / 犬 / 代謝 / メタボローム解析 / 2-ヒドロキシグルタル酸 / イソクエン酸脱水素酵素 / 腫瘍 / 2-HG / 代謝異常 / 血液腫瘍 / 抗がん治療 |
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| Outline of Final Research Achievements |
Canine lymphoma is a frequently occurring malignant tumor. In this study, to identify the target of new treatments, analyzing metabolic analysis was employed using canine lymphoma cells. As a result, although 2-HG has played some role in canine lymphoma cells, no genetic mutation recognized in human tumors was identified. However, it was suggested that the measurement of 2-HG concentration could be applied as a biomarker in canine lymphoma cases. In the future, treatments and diagnosis targeting 2-HG will be advanced by analyzing the mechanism and the functions of the increased 2-HG concentration, and further examining the number of cases.
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| Academic Significance and Societal Importance of the Research Achievements |
リンパ腫は犬の造血器系悪性腫瘍の中で最も発生頻度の高い疾患であり，臨床的にも大きな問題となっている。この疾患への治療は化学療法が第一選択とされ，高い寛解率をもたらすものの，最終的には薬剤耐性の獲得によって治療抵抗性を生じ，死に至る。そのため，今後の治療成績の向上の為に新規の治療法の開発や新たなバイオマーカーが必要とされている。本研究では新たな研究アプローチとして犬リンパ腫細胞を用いた代謝プロファイル解析を行い，その特徴的な代謝産物の同定に成功した。この成果は将来的な診断，治療成績の向上に寄与することが期待される。
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Report
(5 results)
Research Products
(5 results)
