| Project/Area Number |
18K05973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MIYAKE ARIKO 山口大学, 共同獣医学部, 准教授 (20548622)
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| Co-Investigator(Kenkyū-buntansha) |
木村 透 山口大学, 共同獣医学部, 教授 (80419027)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | FeLV / 受容体 / 病原性 / 増殖能 / ウイルス / 病源性 |
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| Outline of Final Research Achievements |
Feline leukemia virus (FeLV) is horizontally transmitted among cats and causes a variety of fatal diseases such as leukemia. In this study, in order to obtain new knowledge on the pathogenicity of FeLV, we analyzed the properties of FeLV-E and FeLV-D, which are newly identified FeLV subgroups. As a result, the infectious receptor which contributed to the pathogenicity of both FeLV was determined, and the cell tropism and the host range of them were also determined. In addition, animal infection experiments of FeLV-D were conducted, and new findings were obtained about the pathogenicity of FeLV at the individual level.
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| Academic Significance and Societal Importance of the Research Achievements |
FeLV感染症はその発見から既に半世紀が経ち実用化されたワクチンも存在するが、未だその制圧には至っておらず獣医臨床上重要な感染症の一つである。しかしながら、近年におけるFeLVの研究は少なく、その内容も疫学的解析やワクチンの評価などに偏っている。本研究においては、FeLVのウイルス学と病原性に関する新たな知見が得られた。これらはFeLV感染症に臨床的に対処していくための基礎的材料にもなると期待される。
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