Role of increased SET expression in myofibroblasts in the "cancer niche"
| Project/Area Number |
18K05994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Sato Koichi 山口大学, 共同獣医学部, 教授 (90205914)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | がん / SET / 筋線維芽細胞 / CAFs / がんニッチ / 微小環境 / がん微小環境 / 癌ニッチ / ホスファターゼ |
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| Outline of Final Research Achievements |
To elucidate the role of increased SET expression in myofibroblasts in the cancer niche, and to provide the basis for anticancer strategies targeting cancer-related myofibroblasts (CAFs), I carried out this project.
As a result of investigating the effect of SET on myofibroblast phenotype and cancer tissue growth using the CAFs-like cell line LmcMF, Smad3 phosphorylation by the CAFs activator TGF-β was promoted by SET KD. It was clarified that the expression of OPG mRNA is suppressed by Smad3 inhibition and that the Smad promoter activity by TGF-β stimulation is promoted by SET KD.From the above, a part of the role of SET in the cancer niche has been clarified.
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| Academic Significance and Societal Importance of the Research Achievements |
がんは人と伴侶動物のどちらにおいても死因の１位となっており、より有効な新規治療法の開発が望まれている。筋線維芽細胞はがん細胞により教育され，癌ニッチにおいて重要な役割を果たすことから創薬標的として注目されている。そのため，正常組織の筋線維芽細胞とがん組織の筋線維芽細胞（CAFs）の違いを明らかにすることが，新規抗がん戦略の創出に不可欠である。
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Report
(4 results)
Research Products
(4 results)
