| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
mTORC1 is a major metabolic signaling complex that activates cellular biosynthesis. In this study, we found that endocytosis inhibitors suppressed cell proliferation and mTORC1 activity in various tumor-derived cell lines. It was also confirmed that endocytosis inhibitors increased the number of S-phase cells and induced apoptosis in a tumor-specific manner.
On the other hand, it has been reported that endocytosis activity increases during amino acid starvation, which is thought to be a mechanism to ensure that cells obtain necessary amino acids. Experiments using dynamin-1/2/3 triple knockout cells revealed that dynamin is involved in this phenomenon.
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