| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It is known that many cancer cells generally maintain telomeric DNA length at chromosome ends, thereby sustaining cancer traits. In this study, we found that the chromatin regulator TAF-I is involved in the regulation of telomere length in human cells through epigenetic regulation of the TERT gene, an enzymatic subunit of telomerase that catalyzes telomeric DNA elongation. The results of this study may provide a partial picture of the mechanism by which TAF-I promotes cellular oncogenesis.
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