| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We discovered a novel sphingolipid, ceramide glyoxylethanolamine (CGE), which does not fit into any conventional category of complexed sphingolipids. Our research suggested that ethanolamine is used for the CGE synthesis via an unknown intermediate, and ceramide structure does not affect the activity of CGE synthase. Fortunately, we could obtain a CGE-deficient mutant strain and found a functionally unknown gene that may be involved in CGE synthesis through genomeic analysis. Novel reaction mechanism and related genes to form unique head group of complexed lipid are expected to be clarified by using CGE-deficient mutant in future research.
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