| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Even though collagen and glycosaminoglycans (GAGs) are the major organic components of bone, little is known about their interaction so far. I have found that GAGs bind to collagen fibrils under acidic conditions to form acid-resistant collagen fibrils. In this year's study, I investigated the degradation of acid-resistant collagen fibrils by cathepsin K using a measurement system with a mass spectrometer that can comprehensively monitor the degradation products of collagen. As a result, the release of peptides from collagen fibrils by cathepsin K tended to be suppressed in the samples in which collagen fibrils bind to chondroitin 4-sulfate to form acid-resistant collagen fibrils.
|
