| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Neurotransmitter is an essential for synaptic transmission in the mammalian central nervous system, and is involved in all brain functions and in various neurological diagnoses. Vesicular neurotransmitter transporters (VNTs) are one of major protein families. They have three isoforms, and transport neurotransmitter into synaptic vesicles for excitatory signal transmission in the central nervous system. VNTs are located not only on synaptic vesicles, but also on the plasma membrane during the transduction of neurons. VNTs are also involved in various biochemical regulation processes. A few VNTs are regarding the functional diversity and differences in the localization of VNTs, more work is needed in order for us to identify all functions and mechanisms of VNTs.
We got new data about the lipid-vesicular neurotransmitter transporter interaction.
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