Explore for tumor markers using glycomics approach
| Project/Area Number |
18K06115
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 43030:Functional biochemistry-related
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Nakano Miyako 広島大学, 統合生命科学研究科(先), 准教授 (40397724)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | グライコミクス / 糖鎖分析 / 質量分析 / 腫瘍マーカー / 糖鎖 / 構造解析 / バイオマーカー / 診断法 |
|---|
| Outline of Final Research Achievements |
We explored novel tumor markers for cancers with a very poor prognosis, that is, three cancers (pancreatic cancer, biliary tract cancer and triple negative breast cancer) for which there are no useful tumor markers that can be diagnosed early or classified correctly. We focused on the glycans on the surface of tumor cells as novel and useful tumor markers. For pancreatic and biliary tract cancers, we found fucosylated haptoglobin. Moreover, we elucidated its production mechanism. For triple negative breast cancer, we found a carrier protein with altered glycan structure. In the future, it will be necessary to investigate the versatility of this tumor marker candidate using a lot of samples. Furthermore, it will be very important to develop a simple and quick measurement method.
|
| Academic Significance and Societal Importance of the Research Achievements |
体の奥深くに潜むため発見が非常に困難な癌（膵臓癌と胆道癌）および標的分子が存在しないため治療薬が無く予後が非常に悪い癌（トリプルネガティブ乳癌）の新規腫瘍マーカーが開発されれば、腫瘍の早期発見および標的治療が可能になり、医療費の削減および国民の健康増進が期待される。
|
Report
(4 results)
Research Products
(15 results)
-
-
-
-
-
-
[Journal Article] Ceramide chain length-dependent protein sorting into selective endoplasmic reticulum exit sites.2020
Author(s)
Sofia Rodriguez-Gallardo, Kazuo Kurokawa, Susana Sabido-Bozo, Alejandro Cortes-Gomez, Atsuko Ikeda, Valeria Zoni, Auxiliadora Aguilera-Romero, Ana Maria Perez-Linero, Sergio Lopez, Miho Waga, Misako Araki, Miyako Nakano, Howard Riezman, Kouichi Funato, Stefano Vanni, Akihiko Nakano, Manuel Muñiz.
-
Journal Title
Science Advances
Volume: 6
Issue: 50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers.2019
Author(s)
Chatterjee S, Lee LY, Kawahara R, Abrahams JL, Adamczyk B, Anugraham M, Ashwood C, Sumer-Bayraktar Z, Briggs MT, Chik JHL, Everest-Dass A, Förster S, Hinneburg H, Leite KRM, Loke I, Möginger U, Moh ESX, Nakano M, その他16名
-
Journal Title
Proteomics
Volume: 19
Issue: 21-22
Pages: 21-22
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods2019
Author(s)
De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Gru Nwald-Grube C, Shao C, Zaia J, Evers W, Pengelley S, Suckau D, Wiechmann A, NakanoM, その他141名
-
Journal Title
Mol Cell Proteomics
Volume: 19(1)
Issue: 1
Pages: 11-30
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
