| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
COPII protein assembles at the endoplasmic reticulum (ER) subdomain ERES and forms transport vesicles that mediate ER export.ER is a network structure that consists of the tubules and the sheets. ERES is known to be generated at high-curvature regions of the ER such as the tubules and edges of the sheets. In this study, I analyzed COPII protein in yeast mutant strain in which the ER structure is disrupted. I show that when the ER structure is altered, the essential function of Sec16, which plays a critical role in ERES formation, can be modulated. The altered ER structure also changes COPII protein assembly. These results provide insight into the functional relevance between the regulation of COPII protein and the structure of the ER.
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