Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
I aim to obtain new insights into novel regulatory mechanisms for metabolic diseases by sPLA2-driven extracellular phospholipid metabolism. We found that (1) sPLA-IID, which preferentially releases ω3 PUFAs possibly from phospholipids in extracellular vesicles, promotes adipocyte browning and thermogenesis, thereby counteracting obesity-associated metabolic complications and WAT inflammation; (2) sPLA-IIE, which produce free fatty acids possibly from phospholipids in extracellular vesicles, promotes adipocyte browning and thermogenesis; (3) sPLA2 receptor deficiency promotes adipocyte browning and thermogenesis.
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