Mechanisms of adipocyte beiging based on extracellular phospholipid metabolism
| Project/Area Number |
18K06128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 43030:Functional biochemistry-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Sato Hiroyasu 東京大学, 大学院医学系研究科(医学部), 助教 (50546629)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脂肪細胞ベージュ化 / ホスホリパーゼA2 / メタボリックシンドローム / リン脂質代謝 / 脂肪酸 / リピドミクス / 脂肪細胞のベージュ化 / エネルギー代謝 / リン脂質 |
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| Outline of Final Research Achievements |
I aim to obtain new insights into novel regulatory mechanisms for metabolic diseases by sPLA2-driven extracellular phospholipid metabolism.
We found that (1) sPLA-IID, which preferentially releases ω3 PUFAs possibly from phospholipids in extracellular vesicles, promotes adipocyte browning and thermogenesis, thereby counteracting obesity-associated metabolic complications and WAT inflammation; (2) sPLA-IIE, which produce free fatty acids possibly from phospholipids in extracellular vesicles, promotes adipocyte browning and thermogenesis; (3) sPLA2 receptor deficiency promotes adipocyte browning and thermogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、ω3脂肪酸の肥満予防効果に新たな学術的理解を与えるとともに、脂肪組織の微小環境においてω3脂肪酸が内因的に動員されるメカニズムを解明した。sPLA2-IID-ω3脂肪酸経路を賦活化する戦略は、肥満や糖尿病などの生活習慣病の新規予防・治療法の開発につながる可能性があり社会的にも重要な成果である。また新たに細胞外リン脂質代謝による脂肪細胞ベージュ化の新たな調節機構の一端を見出したことから学術的な意義が高い。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Prostaglandin E2-EP4 axis promotes lipolysis and fibrosis in adipose tissue leading to ectopic fat deposition and insulin resistance.2020
Author(s)
Inazumi T, Yamada K, Shirata N, Sato H, Taketomi Y, Morita K, Hohjoh H, Tsuchiya S, Oniki K, Watanabe T, Sasaki Y, Oike Y, Ogata Y, Saruwatari J, Murakami M, Sugimoto Y.
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Journal Title
Cell Rep.
Volume: 33
Issue: 2
Pages: 108265-108265
DOI
Related Report
Peer Reviewed / Open Access
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