| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The nucleolus is a site for ribosome biogenesis and surveillance center for this process. Impaired ribosome biogenesis, which is detected in the nucleolus, induces nucleolar stress response, eventually leading to p53 activation, followed by cell cycle arrest and/or apoptotic cell death. In this study, we found that (1) a particular region of pre-rRNA regulates the binding of nucleolar protein PICT1 and its stabilizer X; (2) nucleolar stress decreased the amount of pre-rRNA to induce dissociation of PICT1-X complex; (3) the dissociated PICT1 became unstable and degraded then triggered the signal that led to p53 activation.
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