| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Invadopodia in invasive cancer cells are actin-enriched structures with an ability to degrade extracellular matrix (ECM) and play crucial roles in invasion and metastasis. A formation of functional invadopodia may require a crosstalk between microtubules and actin filaments, but the molecular mechanisms are not fully understood. In addition, regulatory mechanisms of the polarized transport of metalloproteinases degrading ECM at invadopodia remain elusive. In this study, we have focused on the microtubule-associated protein (MAP) that is associated with the crosstalk between microtubules and actin filaments and the SNARE proteins that function in the transport of metalloproteinases to invadopodia and revealed a part of the molecular mechanisms of invadopodia formation followed by cancer metastasis.
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