| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Mouse ES cells are pluripotent stem cells; they differentiate into epiblast or primitive endoderm when the differentiation is triggered. On the other hand, studies including us have revealed that signal receptors are selectively localized in lipid rafts on the cell membrane, and that localization is essential for signal transduction.
In this study, we focused on the glycolipids that constitute lipid rafts in mouse ES cells and analyzed changes in their composition during differentiation of mouse ES cells into epiblast stem cells. Then, we found a novel mechanism that totally controls the glycosyltransferases responsible for these changes. These results suggest that glycolipid changes may be involved in the exit from undifferentiation state and the decision to differentiate.
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