| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Respiratory chains in mitochondrial and bacterial membrane transfer hydrogen ions (protons) by using energy released from the redox reaction (electron transfer), and efficiently generates energy available for the life. To understand the energy transduction mechanism of the respiratory terminal enzymes, I studied molecular structure and function of mitochondrial cytochrome c oxidase and bacterial nitric oxide reductases. The resolution of structural analysis was improved. The results showed structural changes of the enzymes depending on the reaction with the substrates and inhibitors, and indicated the regulation mechanism of enzymatic activity depending on the monomerization/dimerization of enzyme.
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